{"id":"W2911507042","doi":"10.1182/blood-2018-99-118501","title":"Cell Type-Specific Deregulation of Polypyrimidine Tract- Binding Proteins (PTBPs) Drive Aberrant Splicing in Multiple Myeloma (MM) and Acute Myeloid Leukemia (AML)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Downregulation and upregulation; Myeloid leukemia; Cancer research; Myeloid; Biology; RNA splicing; Cell culture; Molecular biology; Stromal cell; Intron; Bone marrow; Polypyrimidine tract-binding protein; Transcriptome; Immunology; Gene expression; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341439,0.0001069926,0.0001867334,0.000298289,0.0001366548,0.0002601076,0.0001033885,0.0001499615,0.001164723],"category_scores_gemma":[0.0001125187,0.0001495341,0.0001866889,0.0002983641,0.0001310355,0.00009087793,0.0002256839,0.0002863762,0.0003451323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883882,"about_ca_system_score_gemma":0.00008980009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004668418,"about_ca_topic_score_gemma":0.0009696721,"domain_scores_codex":[0.9998249,0.00001998226,0.00001708914,0.00005260402,0.00005512622,0.00003031655],"domain_scores_gemma":[0.9999365,0.00001095187,0.00002401951,0.000007393272,0.00000698811,0.00001413067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000773889,0.0000115788,0.003744135,0.00001608234,0.000006474751,0.00002918336,0.000019338,0.00003446862,0.994814,0.00002674239,0.00004146918,0.001178951],"study_design_scores_gemma":[0.00002036537,0.000333774,0.3008379,0.000007689119,0.00005203798,0.0009382988,0.0001634634,0.001816725,0.6925299,0.0001160349,0.003177328,0.000006467093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997915,0.0004286805,0.0007161276,0.00002299871,0.00000639194,0.00000722765,0.0005616039,0.00002830476,0.0003135746],"genre_scores_gemma":[0.9977127,0.0002367104,0.0006278303,0.00002648341,0.000002682209,0.00001492926,0.0007023344,0.000007429613,0.0006687289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164723,"threshold_uncertainty_score":0.003896415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01474896856170544,"score_gpt":0.2430640492853024,"score_spread":0.2283150807235969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}