{"id":"W2911517623","doi":"10.1016/j.abb.2019.02.007","title":"Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity","year":2019,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Social Fund; State Scholarships Foundation","keywords":"Ionomycin; Gene silencing; Phosphatase; Calcineurin; Small interfering RNA; Cell biology; Kinase; Transcription factor; Biology; Phosphorylation; RNA interference; Molecular biology; Chemistry; Biochemistry; Intracellular; Gene; Transplantation; Transfection; RNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004152552,0.000247827,0.0002594363,0.00002640606,0.00006108994,0.00001910899,0.0001925694,0.000129245,0.0000276857],"category_scores_gemma":[0.00001556828,0.0002320229,0.0001747286,0.00007838912,0.0002402293,0.00001203966,0.0001022961,0.0001308383,0.000004132391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003718942,"about_ca_system_score_gemma":0.00009589376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002622667,"about_ca_topic_score_gemma":0.000001432801,"domain_scores_codex":[0.9988573,0.00002631389,0.000186861,0.0005127537,0.0001510646,0.0002656815],"domain_scores_gemma":[0.9992814,0.00001753941,0.0001191325,0.0004228987,0.00003167299,0.0001273547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003683635,0.0001804826,0.0002433756,0.000219153,0.00007045005,4.216864e-7,0.00003985532,0.000004837962,0.9844082,0.0001887596,0.00006837156,0.01420773],"study_design_scores_gemma":[0.000895254,0.0001705844,0.006797586,0.00004692783,0.00002369847,0.000006653139,0.00002529653,0.00003902585,0.9839589,0.0002787763,0.007480183,0.0002771049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961175,0.002090893,0.0001170233,0.00008289916,0.000184665,0.0002648962,0.0005261355,0.00001324197,0.0006027186],"genre_scores_gemma":[0.9966939,0.0003630404,0.0004669846,0.00004210797,0.0005789451,0.00001847429,0.0002428193,0.00002034224,0.001573351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01393062,"threshold_uncertainty_score":0.9461619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007900800748139564,"score_gpt":0.2187404366131325,"score_spread":0.2108396358649929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}