{"id":"W2911517623","doi":"10.1016/j.abb.2019.02.007","title":"Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity","year":2019,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Social Fund; State Scholarships Foundation","keywords":"Ionomycin; Gene silencing; Phosphatase; Calcineurin; Small interfering RNA; Cell biology; Kinase; Transcription factor; Biology; Phosphorylation; RNA interference; Molecular biology; Chemistry; Biochemistry; Intracellular; Gene; Transplantation; Transfection; RNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753684,0.0002806703,0.000321957,0.0003979723,0.0003109325,0.0005735636,0.0002770292,0.0002965398,0.002136415],"category_scores_gemma":[0.0002482845,0.0002495669,0.0004144,0.0003417315,0.0004394077,0.0002334003,0.0003465952,0.0007981141,0.000460461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005844778,"about_ca_system_score_gemma":0.0007789533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003310856,"about_ca_topic_score_gemma":0.003481232,"domain_scores_codex":[0.9997494,0.00002432548,0.00001975329,0.00005826671,0.0000572438,0.00009102534],"domain_scores_gemma":[0.9998423,0.00002469556,0.00003194877,0.0000200776,0.00002021045,0.0000606926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002625605,0.00003063441,0.0002735952,0.00002544686,0.000007246057,0.00007765256,0.00001134872,0.00004347837,0.9976971,0.0002118368,0.0001328664,0.00122626],"study_design_scores_gemma":[0.0000543347,0.000141238,0.008411584,0.000004753893,0.00002242174,0.0002775613,0.00004080608,0.001425466,0.9854183,0.0001558088,0.004041622,0.00000604462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862031,0.004790963,0.00362669,0.0005761565,0.0002783336,0.00004077732,0.0007879329,0.0002601581,0.003435997],"genre_scores_gemma":[0.993831,0.001068224,0.0008800572,0.0001032361,0.00002880618,0.00002884142,0.000549692,0.00003217226,0.003477971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003310856,"threshold_uncertainty_score":0.007147014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007900800748139564,"score_gpt":0.2187404366131325,"score_spread":0.2108396358649929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}