{"id":"W2911536945","doi":"10.1080/14728222.2019.1581764","title":"Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape","year":2019,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Agmatine; Polyamine; Neuroprotection; Antidepressant; Bipolar disorder; Depression (economics); Neuroscience; Medicine; Pathophysiology; Inflammation; Pharmacology; Bioinformatics; Biology; Internal medicine; Hippocampus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"not_applicable","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005308616,0.0007522879,0.001783101,0.0003061136,0.0001338438,0.00006300674,0.0004302139,0.0006458223,0.00121627],"category_scores_gemma":[0.00004085269,0.0004177942,0.001256128,0.0003246676,0.00008542225,0.00007565868,0.0001218655,0.001058283,0.0007899482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527511,"about_ca_system_score_gemma":0.0002420965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006756347,"about_ca_topic_score_gemma":0.00001560248,"domain_scores_codex":[0.996152,0.0008053143,0.001069877,0.0008458132,0.0006066373,0.0005203804],"domain_scores_gemma":[0.9978834,0.0003518841,0.0004405981,0.001122263,0.0000550627,0.0001467296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000281972,0.001281031,0.0002565072,0.001266637,0.0007894214,0.00001080893,0.0003029096,0.000001029692,0.000001747851,0.0001306005,0.000276648,0.9954007],"study_design_scores_gemma":[0.002759655,0.0009508257,0.0008274345,0.005171981,0.0003244871,0.000201249,0.00009150182,0.00008252032,0.000005634529,0.000134536,0.9890506,0.0003996074],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[5.093956e-7,0.9938139,0.0001178167,0.0007390133,0.001901243,0.00270371,0.00002085996,0.00009955123,0.0006033711],"genre_scores_gemma":[0.001250851,0.9955243,0.00004333806,0.0007843571,0.0005684844,0.0005817224,0.0005741385,0.0001399276,0.0005328925],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950011,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07289562796849804,"score_gpt":0.4078969371143986,"score_spread":0.3350013091459005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}