{"id":"W2911538469","doi":"10.1093/ecco-jcc/jjy222.079","title":"DOP45 Adequate infliximab exposure during the induction phase is associated with early complete fistula response in patients with fistulizing Crohn’s disease: a post-hoc analysis of the ACCENT-2 trial","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Medicine; Infliximab; Interquartile range; Crohn's disease; Internal medicine; Post-hoc analysis; Logistic regression; Odds ratio; Confidence interval; Receiver operating characteristic; Area under the curve; Concordance; Gastroenterology; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004489655,0.0006832158,0.001874001,0.0002093754,0.0001791222,0.001211327,0.0004373365,0.0006538869,0.00169583],"category_scores_gemma":[0.003949697,0.000270506,0.002836286,0.0002196949,0.000360567,0.000793306,0.0005424067,0.001465994,0.0001985795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103629,"about_ca_system_score_gemma":0.0002898484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001544726,"about_ca_topic_score_gemma":0.0002722325,"domain_scores_codex":[0.9974993,0.001647354,0.0001624347,0.0003014333,0.0001594978,0.0002299675],"domain_scores_gemma":[0.9952224,0.003005628,0.0007764411,0.0004705448,0.0001453041,0.0003795791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7745936,0.001190948,0.186359,0.0005204009,0.01102005,0.0002966031,0.0001856362,0.001359202,0.005202657,0.0001383153,0.001174336,0.01795917],"study_design_scores_gemma":[0.04523302,0.1144323,0.8023987,0.0001100682,0.01675226,0.0007417029,0.00025651,0.01090752,0.004587463,0.0004653438,0.003994749,0.000120311],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978657,0.001137137,0.0001958785,0.00007007269,0.00004692377,0.00004900996,0.0001853996,0.00000868269,0.0004412705],"genre_scores_gemma":[0.9988059,0.000127026,0.0001774553,0.00007921136,0.00008008739,0.00005958218,0.0003405638,0.000005578477,0.0003245774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004489655,"threshold_uncertainty_score":0.02374387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007037074513403428,"score_gpt":0.2288772518230858,"score_spread":0.2218401773096824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}