{"id":"W2911563907","doi":"10.1128/jvi.01871-18","title":"Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Montreal Clinical Research Institute; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Viral replication; Virology; Virus; In vivo; Cytopathic effect; Immunity; Mdm2; Human immunodeficiency virus (HIV); Immune system; Permissiveness; Cell culture; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038695,0.0001965976,0.0002086371,0.0002061381,0.000235074,0.0002813973,0.0001125202,0.0002019707,0.001632452],"category_scores_gemma":[0.0001564246,0.00007193616,0.000166638,0.00008736959,0.0002595153,0.0002024774,0.0001818197,0.000428088,0.0002771782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208917,"about_ca_system_score_gemma":0.0001623058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547497,"about_ca_topic_score_gemma":0.0002644571,"domain_scores_codex":[0.9998646,0.00003815575,0.00001013595,0.00001743785,0.00002372785,0.00004600505],"domain_scores_gemma":[0.999894,0.00002843364,0.00001886821,0.00001642316,0.00001332487,0.00002887355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000333232,0.00005850242,0.0007452822,0.00003767756,0.000004408746,0.0001146169,0.00002019165,0.00003720506,0.9967119,0.0001734241,0.00005070346,0.001712934],"study_design_scores_gemma":[0.00002544798,0.0005243059,0.006840644,0.000009829277,0.00001287233,0.0004623421,0.00007191092,0.0005035939,0.9888782,0.000181274,0.002486419,0.000003247577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953608,0.002066026,0.001524115,0.0001691561,0.0000314115,0.00001064551,0.00007446933,0.00002941147,0.000734055],"genre_scores_gemma":[0.9974806,0.0006206306,0.0005223294,0.00002148413,0.00001589048,0.00001480102,0.000073104,0.00000536534,0.001245852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632452,"threshold_uncertainty_score":0.005461097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009950173607054406,"score_gpt":0.2573440444976228,"score_spread":0.2473938708905684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}