{"id":"W2911571221","doi":"10.1159/000495658","title":"Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder","year":2019,"lang":"en","type":"review","venue":"Complex Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Novo Nordisk; Assurex Health; University of Louisville; Ministry of Education, India; National Institute of Mental Health; Pfizer; Johns Hopkins University; Mayo Foundation for Medical Education and Research; University of Pennsylvania; Lundbeckfonden; H. Lundbeck A/S; Rush University; Wayne State University","keywords":"Mitochondrial DNA; Genetics; Bipolar disorder; Biology; Epistasis; Nuclear gene; Population stratification; Gene; Mitochondrion; Single-nucleotide polymorphism; Genotype; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000111356,0.0003633916,0.001014773,0.0001681914,0.0001049659,0.00003275549,0.0002208914,0.0004096395,0.0001002763],"category_scores_gemma":[0.00006064812,0.0003450257,0.0001879625,0.0001313351,0.0001168844,0.00000340095,0.0002802357,0.0002964451,0.00004964049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001796975,"about_ca_system_score_gemma":0.0001040574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006107218,"about_ca_topic_score_gemma":0.0003572076,"domain_scores_codex":[0.9982949,0.0001609683,0.0005459886,0.0006345891,0.00006424858,0.0002993279],"domain_scores_gemma":[0.9990899,0.00005948411,0.0003047518,0.0004206538,0.00002259595,0.0001026147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006095381,0.0003447385,0.03324667,0.003587919,0.001014831,7.393155e-7,0.0000622033,0.000003334726,0.0008380258,0.001810441,0.04213693,0.9168932],"study_design_scores_gemma":[0.0007135035,0.00008514617,0.03058775,0.0003606217,0.0001983783,0.00002576763,0.00002550082,0.00002236526,3.14867e-8,0.00005882695,0.9675794,0.0003427481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004524599,0.9925323,0.0003438958,0.0002087128,0.0006792402,0.0006203289,0.0002745235,0.00001720661,0.0007991976],"genre_scores_gemma":[0.0006658104,0.9801103,0.01637531,0.000141361,0.001020802,0.00003294047,0.001000934,0.0001301266,0.0005223632],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9254425,"threshold_uncertainty_score":0.9999002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05900646145967196,"score_gpt":0.3379445287624866,"score_spread":0.2789380673028146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}