{"id":"W2911578183","doi":"10.1038/s41419-019-1359-x","title":"Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Yarmouk University; Research Manitoba","keywords":"Mesenchymal stem cell; Proteasome; Immune system; MHC class I; Immunogenicity; Transplantation; Cell biology; Biology; Immunology; Major histocompatibility complex; Cancer research; Chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128957,0.0001816608,0.0002053054,0.0001133659,0.00008696827,0.0001929523,0.00006064383,0.0001281031,0.001247475],"category_scores_gemma":[0.00008281978,0.00007899449,0.0002155175,0.00006396941,0.00009558329,0.0001333681,0.0001286814,0.0002992609,0.0001689051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203041,"about_ca_system_score_gemma":0.0001280101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941378,"about_ca_topic_score_gemma":0.0001948875,"domain_scores_codex":[0.9999094,0.00001465702,0.00001156605,0.00001640425,0.00002135037,0.00002662322],"domain_scores_gemma":[0.9999127,0.000007451564,0.00003455388,0.000007255884,0.00001028775,0.00002770475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676731,0.00004637124,0.0007682967,0.00005218812,0.00001178217,0.00008515704,0.00001563024,0.0000318662,0.9969389,0.0000379985,0.00005649483,0.001687669],"study_design_scores_gemma":[0.00003036776,0.001458436,0.04977309,0.00001202315,0.00005533744,0.0007841052,0.00007828249,0.0007665888,0.9443015,0.0001080343,0.002625578,0.000006508331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995388,0.002525113,0.0009372056,0.0001007171,0.00005949902,0.00001565516,0.0001672276,0.00002798019,0.0007785981],"genre_scores_gemma":[0.9979106,0.0008281608,0.0002521781,0.00005685266,0.00002135131,0.00001345057,0.0002063623,0.000005386175,0.0007057101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247475,"threshold_uncertainty_score":0.00417316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134622061902069,"score_gpt":0.210003118187721,"score_spread":0.1986568975687004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}