{"id":"W2911578183","doi":"10.1038/s41419-019-1359-x","title":"Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Yarmouk University; Research Manitoba","keywords":"Mesenchymal stem cell; Proteasome; Immune system; MHC class I; Immunogenicity; Transplantation; Cell biology; Biology; Immunology; Major histocompatibility complex; Cancer research; Chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257985,0.000180102,0.0001732902,0.00003813739,0.00006086846,0.00002032401,0.0001206246,0.0001084357,0.00007727971],"category_scores_gemma":[0.00002548633,0.0001646501,0.000116982,0.00005540118,0.00003628117,0.000008379106,0.0001161669,0.00006991163,0.0000382179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008336286,"about_ca_system_score_gemma":0.0001663199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005292986,"about_ca_topic_score_gemma":0.00000119485,"domain_scores_codex":[0.9989855,0.00008182658,0.0001935568,0.0003678054,0.0001407934,0.0002304785],"domain_scores_gemma":[0.9990723,0.00001386664,0.0001030507,0.000386258,0.00006960621,0.0003549425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006124222,0.000178428,0.01352454,0.0002065001,0.00002260647,0.000005367209,0.00001570871,0.000006097619,0.9842449,0.00007052026,0.0001116281,0.001001246],"study_design_scores_gemma":[0.001176757,0.0004195943,0.01223664,0.00002636224,0.00005370762,0.000004083603,0.00005685152,0.0000777499,0.9841708,0.0001198841,0.001417631,0.0002399513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952549,0.002138135,0.00005036275,0.00001235457,0.0001121975,0.0005982294,0.00009883939,0.00001589919,0.001719034],"genre_scores_gemma":[0.9981763,0.0001284129,0.00007129006,0.0001153166,0.00009573634,0.00004101802,0.0000732527,0.00001919012,0.001279518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002921317,"threshold_uncertainty_score":0.6714237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134622061902069,"score_gpt":0.210003118187721,"score_spread":0.1986568975687004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}