{"id":"W2911595146","doi":"10.1038/s41467-019-08380-1","title":"SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; BC Cancer Agency; Montreal Children's Hospital; University of British Columbia; McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; McGill University Health Centre; Canadian Institutes of Health Research; Cancer Research Society","keywords":"SMARCA4; Cyclin D1; Cancer research; Biology; Lung cancer; Cyclin D; Etoposide; Cell growth; Chromatin; Medicine; Cancer; Cell cycle; Chromatin remodeling; Internal medicine; Gene; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010093,0.0001165366,0.000107881,0.00004187224,0.00006814559,0.00001696092,0.0003068851,0.0002628551,0.00003558018],"category_scores_gemma":[0.000008938273,0.0001054481,0.00004658922,0.0001361433,0.0000568055,0.000004014871,0.0001612977,0.0004489871,0.00001067494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004758771,"about_ca_system_score_gemma":0.0001198957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346532,"about_ca_topic_score_gemma":0.001157591,"domain_scores_codex":[0.9993394,0.00004902773,0.0001379057,0.0002306222,0.00008861206,0.0001544477],"domain_scores_gemma":[0.9986289,0.00002074955,0.00006855842,0.001148312,0.00009819591,0.00003529927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002052092,0.0006626704,0.1455772,0.0003841196,0.0001444601,0.000006860108,0.001630907,0.00400358,0.8330384,0.0004360687,0.01083799,0.003072482],"study_design_scores_gemma":[0.007395362,0.0005390673,0.04839206,0.00179606,0.0002601524,0.000118334,0.0009840099,0.04327644,0.794138,0.0002188558,0.1006814,0.002200337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839113,0.008814658,0.0001712267,0.001328873,0.00007001955,0.0002694597,0.00003471049,0.00001134624,0.005388409],"genre_scores_gemma":[0.9956652,0.001318165,0.001510188,0.0005992379,0.00004329503,0.00007571089,0.0001419182,0.00002225629,0.0006240262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09718513,"threshold_uncertainty_score":0.430005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006623026746210639,"score_gpt":0.2669261178948399,"score_spread":0.2603030911486293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}