{"id":"W2911595146","doi":"10.1038/s41467-019-08380-1","title":"SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; BC Cancer Agency; Montreal Children's Hospital; University of British Columbia; McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; McGill University Health Centre; Canadian Institutes of Health Research; Cancer Research Society","keywords":"SMARCA4; Cyclin D1; Cancer research; Biology; Lung cancer; Cyclin D; Etoposide; Cell growth; Chromatin; Medicine; Cancer; Cell cycle; Chromatin remodeling; Internal medicine; Gene; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048516,0.0004263806,0.0004000007,0.0004068427,0.0002270293,0.0003008342,0.0002766831,0.000442956,0.001970619],"category_scores_gemma":[0.0001615423,0.0002125863,0.0003408318,0.0001881301,0.0002676469,0.0001843478,0.0002368633,0.0006171683,0.000454633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003766966,"about_ca_system_score_gemma":0.0003086628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007623582,"about_ca_topic_score_gemma":0.00126635,"domain_scores_codex":[0.9998176,0.00003996015,0.00001952566,0.00002623366,0.00006040545,0.00003629673],"domain_scores_gemma":[0.9998372,0.00003214892,0.00003955456,0.00002484991,0.000008894145,0.0000572952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002965834,0.0000962512,0.0005790398,0.00003610642,0.00002165661,0.0002222916,0.00000734282,0.0003220534,0.9954143,0.0002354693,0.0002167077,0.002552242],"study_design_scores_gemma":[0.00007345991,0.00132382,0.008680447,0.000006788273,0.00002838215,0.001643071,0.0000283838,0.002136175,0.9803801,0.0001459986,0.005545608,0.000007719576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910302,0.003140829,0.00172853,0.0002630381,0.00006264061,0.00004489823,0.0006598583,0.0002259252,0.002844026],"genre_scores_gemma":[0.9956782,0.0007952491,0.0006998682,0.00005859897,0.000008076102,0.00003252618,0.0006296498,0.00002127804,0.002076598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970619,"threshold_uncertainty_score":0.006592393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006623026746210639,"score_gpt":0.2669261178948399,"score_spread":0.2603030911486293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}