{"id":"W2911638808","doi":"10.1016/j.chemosphere.2019.01.141","title":"Exposure to dilute concentrations of bupropion affects zebrafish early life stages","year":2019,"lang":"en","type":"article","venue":"Chemosphere","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro; Ministério da Educação; Ministério da Ciência, Tecnologia e Ensino Superior; Associação Médica Brasileira; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Diagnostic Services Manitoba; ASCRS Research Foundation","keywords":"Zebrafish; Danio; Aché; Acetylcholinesterase; Bupropion; Catalase; Chemistry; Lactate dehydrogenase; Toxicity; Glutathione; Hatching; Acute toxicity; Reuptake; Pharmacology; Toxicology; Internal medicine; Antioxidant; Biology; Enzyme; Biochemistry; Serotonin; Animal science; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106884,0.0001168053,0.0001487763,0.00001082326,0.00003844107,0.00002310237,0.000290842,0.0001438491,0.0003447773],"category_scores_gemma":[0.0002968805,0.0001097396,0.00006804086,0.0002081609,0.00008787811,0.000005912752,0.0001413037,0.00009629584,0.0001518095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001535349,"about_ca_system_score_gemma":0.0001726758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002430107,"about_ca_topic_score_gemma":0.00002162136,"domain_scores_codex":[0.9989495,0.00002961715,0.0001659514,0.000332275,0.0002532554,0.0002693846],"domain_scores_gemma":[0.99896,0.00002631953,0.00006087042,0.0005203832,0.0001342761,0.0002981979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003975957,0.00007553389,0.0145299,0.00004866598,0.0000357914,5.415633e-7,0.00004005697,0.00001319555,0.9678905,0.0002853381,0.01529214,0.001748587],"study_design_scores_gemma":[0.0007160548,0.0007171597,0.07743651,0.00003378148,0.000009456485,0.000001071013,0.00008113337,0.00001646386,0.8651178,0.00005790307,0.05561856,0.0001941064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939336,0.0002402765,0.00104397,0.001011895,0.00005600539,0.0006110307,0.00004709272,0.00001915476,0.003036932],"genre_scores_gemma":[0.9961613,0.00003512671,0.001057395,0.0004132757,0.0001148982,0.00007229185,0.0001053707,0.00002119198,0.002019163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1027727,"threshold_uncertainty_score":0.447505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007212387783944191,"score_gpt":0.2556402155798487,"score_spread":0.2484278277959045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}