{"id":"W2911662151","doi":"10.1016/j.bpj.2018.11.1109","title":"Dynamic Interactions between an Intrinsically Disordered Protein and its Binding Partners Probed by Multiparameter Single-Molecule Fluorescence","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Intrinsically disordered proteins; Phosphorylation; Cyclin-dependent kinase; Biophysics; Förster resonance energy transfer; Chemistry; Cell biology; Ubiquitin ligase; Protein–protein interaction; Ubiquitin; Biochemistry; Biology; Fluorescence; Cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008763272,0.0002332743,0.0002228387,0.00006064652,0.0001278889,0.0001166075,0.0002616006,0.0001286903,0.000009667871],"category_scores_gemma":[0.00007942111,0.0002092159,0.00008404685,0.0001101652,0.0001148643,0.00004899215,0.0001447304,0.0003829275,0.0000181062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004732552,"about_ca_system_score_gemma":0.000037673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002175971,"about_ca_topic_score_gemma":0.000002146464,"domain_scores_codex":[0.9986516,0.00009583424,0.0002795126,0.0004436095,0.000165472,0.0003639625],"domain_scores_gemma":[0.9992681,0.00001546502,0.0001647292,0.0002340783,0.0001000549,0.0002176425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008765338,0.0001756443,0.000563358,0.00001231582,0.00002832591,0.000002583831,0.00002903626,0.0000018565,0.9951278,0.00001314691,0.00006126697,0.003897037],"study_design_scores_gemma":[0.0004469415,0.0009241681,0.0003267106,0.00007189751,0.00001517079,0.00002499389,0.00003655772,0.0007866842,0.9961851,0.00004011786,0.0008477104,0.0002939344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855258,0.00004003172,0.01368683,0.0001409799,0.00005712127,0.0004578484,0.00003252905,0.00003612641,0.00002273076],"genre_scores_gemma":[0.9803944,0.00002603291,0.01909648,0.00004133222,0.000100038,0.00002464257,0.00008209114,0.00003900779,0.0001959522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005409651,"threshold_uncertainty_score":0.8531577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138614950633795,"score_gpt":0.3025596966169459,"score_spread":0.291173547110608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}