{"id":"W2911690480","doi":"10.26508/lsa.201800186","title":"Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Foundation to Eradicate Duchenne; Children’s Hospital of Wisconsin Research Institute; Action Duchenne; National Institutes of Health; National Heart, Lung, and Blood Institute; Intellectual and Developmental Disabilities Research Center; U.S. Department of Defense","keywords":"Eplerenone; Mineralocorticoid receptor; Cardiomyopathy; Endocrinology; Duchenne muscular dystrophy; Medicine; Receptor; Internal medicine; Inflammation; Nuclear receptor; Biology; Transcription factor; Heart failure; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816757,0.0001006473,0.0001100165,0.00003013352,0.000127442,0.0000267637,0.000177248,0.00006602998,0.00003324742],"category_scores_gemma":[0.0001104909,0.00009481332,0.00002672613,0.0001754487,0.0002241432,0.00001865489,0.0001183863,0.00005101675,0.0001406846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008397142,"about_ca_system_score_gemma":0.00006500358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000010441,"about_ca_topic_score_gemma":0.000003110053,"domain_scores_codex":[0.9990637,0.00002454877,0.0001037781,0.0004285661,0.0001304605,0.0002489626],"domain_scores_gemma":[0.999486,0.00000481783,0.00004100514,0.0002688243,0.00005216323,0.0001471395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009774351,0.000009102453,0.004454345,0.00001101465,0.000004739002,5.777815e-7,0.0001083029,0.0004472466,0.9923104,0.0002029826,0.000626057,0.001727455],"study_design_scores_gemma":[0.002866311,0.003537819,0.4102723,0.00007892216,0.00004051252,0.00002727032,0.0009373218,0.001548941,0.4489214,0.0007656658,0.1294159,0.001587664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975996,0.0002673353,0.00005131617,0.0006293892,0.0002427617,0.0001751796,0.00000306946,0.00001269075,0.001018631],"genre_scores_gemma":[0.9984701,0.0001285046,0.0004555066,0.0005267459,0.0001285398,0.000008891398,0.000008292317,0.000008090099,0.0002653338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.543389,"threshold_uncertainty_score":0.3866375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005286086187350676,"score_gpt":0.2218604267471904,"score_spread":0.2165743405598397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}