{"id":"W2911690480","doi":"10.26508/lsa.201800186","title":"Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Foundation to Eradicate Duchenne; Children’s Hospital of Wisconsin Research Institute; Action Duchenne; National Institutes of Health; National Heart, Lung, and Blood Institute; Intellectual and Developmental Disabilities Research Center; U.S. Department of Defense","keywords":"Eplerenone; Mineralocorticoid receptor; Cardiomyopathy; Endocrinology; Duchenne muscular dystrophy; Medicine; Receptor; Internal medicine; Inflammation; Nuclear receptor; Biology; Transcription factor; Heart failure; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830338,0.0002907075,0.0002962495,0.0003064502,0.0001364512,0.0002652867,0.000222648,0.0003910521,0.001968626],"category_scores_gemma":[0.00007228763,0.0000785668,0.0002453781,0.0001306241,0.0001948949,0.0001565026,0.0002433943,0.0006943565,0.0004855016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357392,"about_ca_system_score_gemma":0.0002489516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000280389,"about_ca_topic_score_gemma":0.001305328,"domain_scores_codex":[0.9998499,0.00003137555,0.00001165421,0.00002489074,0.00004926506,0.00003293524],"domain_scores_gemma":[0.9999229,0.000007985711,0.00002427869,0.000007139513,0.00001421488,0.00002355272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005382846,0.0000958903,0.0005544703,0.0002883685,0.00004320924,0.0002528743,0.0000292457,0.0001309947,0.9620754,0.0006980851,0.0008636777,0.03442962],"study_design_scores_gemma":[0.0006728448,0.006582593,0.01188853,0.0001733591,0.0002268508,0.005646715,0.0001112886,0.001056934,0.842451,0.0006732626,0.1304727,0.00004394031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7762501,0.1808552,0.0172783,0.003041235,0.0007150969,0.0002284469,0.001140932,0.0008638849,0.01962675],"genre_scores_gemma":[0.9545693,0.02695896,0.005011229,0.0008746555,0.0001285062,0.00009181857,0.0008442996,0.00003670546,0.0114846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968626,"threshold_uncertainty_score":0.006585717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005286086187350676,"score_gpt":0.2218604267471904,"score_spread":0.2165743405598397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}