{"id":"W2911702342","doi":"10.1080/14656566.2019.1570132","title":"An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma","year":2019,"lang":"en","type":"review","venue":"Expert Opinion on Pharmacotherapy","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Roflumilast; Medicine; Asthma; Intensive care medicine; Internal medicine; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219995,0.0002742685,0.0004340866,0.00007608972,0.00004200619,0.000009850321,0.00008427123,0.0001420829,0.00005864682],"category_scores_gemma":[0.00000324683,0.0001452629,0.0001525112,0.00007978444,0.00006674782,0.000004138171,0.000005318919,0.00004915806,0.000002435409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004372196,"about_ca_system_score_gemma":0.0001265613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009568381,"about_ca_topic_score_gemma":0.000001536934,"domain_scores_codex":[0.9986411,0.000365333,0.0002791262,0.0003305681,0.0002862635,0.00009757443],"domain_scores_gemma":[0.9991533,0.00003410047,0.0003167142,0.0003556833,0.00009789887,0.0000423044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003786726,0.000433652,0.000004429442,0.0001289011,0.0002547266,8.498726e-8,0.0001946444,0.00003279297,0.01033197,0.00004271269,0.0007149852,0.9874824],"study_design_scores_gemma":[0.001469874,0.004039355,0.000007792974,0.0007766543,0.00003510457,0.000003833587,0.0000287091,0.00008212728,0.08715187,0.00000337664,0.9062409,0.0001604312],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005577581,0.9924681,0.00002722479,0.00007403741,0.0004593781,0.001214979,0.00003526829,0.000005978952,0.0001374876],"genre_scores_gemma":[0.004734088,0.9943453,0.00002003596,0.00008890393,0.0003372208,0.0001768563,0.0001978479,0.00003849452,0.00006124394],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.987322,"threshold_uncertainty_score":0.5923651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07748991243654003,"score_gpt":0.4016291271319666,"score_spread":0.3241392146954266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}