{"id":"W2911720118","doi":"10.1182/blood-2018-99-120229","title":"Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Biology; Genetics; Genome-wide association study; Single-nucleotide polymorphism; Chromatin; Gene; Computational biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004625357,0.0003714235,0.0004069057,0.0006932972,0.0001541203,0.0005030461,0.0002876288,0.0003136891,0.002281036],"category_scores_gemma":[0.0005039981,0.0001937725,0.0005233086,0.0006829798,0.0002673933,0.000151185,0.0005105885,0.0006409251,0.0003383873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253975,"about_ca_system_score_gemma":0.0002443579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008691691,"about_ca_topic_score_gemma":0.001435139,"domain_scores_codex":[0.9995626,0.00005402138,0.00003623982,0.0001820709,0.000108551,0.00005653762],"domain_scores_gemma":[0.9994941,0.0001641415,0.0001863337,0.00007095047,0.00003747681,0.00004698112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002463676,0.00003368064,0.0154828,0.00009046571,0.0001895238,0.0002494004,0.00004596925,0.0008612034,0.9733642,0.00043338,0.0001269276,0.008876283],"study_design_scores_gemma":[0.00008089598,0.0007233804,0.447232,0.00004310611,0.0009486655,0.001800022,0.0001268228,0.01374574,0.5252094,0.001942482,0.008076071,0.00007138364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740737,0.001033274,0.01905936,0.0001046794,0.0000240868,0.00003129997,0.004242144,0.000338804,0.001092721],"genre_scores_gemma":[0.9902501,0.0002806424,0.006696645,0.0001225551,0.00000648545,0.00002276113,0.001709869,0.00005663039,0.0008544115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002281036,"threshold_uncertainty_score":0.007630825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007157463926986183,"score_gpt":0.2443759389051358,"score_spread":0.2372184749781496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}