{"id":"W2911725572","doi":"10.1016/j.stem.2019.01.002","title":"EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Canada; Ontario Institute for Regenerative Medicine; AFM-Téléthon; Stem Cell Network; Muscular Dystrophy Association","keywords":"Biology; Cell biology; Dystrophin; Regeneration (biology); Duchenne muscular dystrophy; Mitosis; Asymmetric cell division; Stem cell; Progenitor cell; Skeletal muscle; Centrosome; Cancer research; Cell division; Cell cycle; Cell; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145876,0.0005194484,0.00040945,0.0006209645,0.0002776278,0.0004574576,0.0005484165,0.0004891542,0.002440201],"category_scores_gemma":[0.0001336584,0.0003263064,0.0003709095,0.0002351697,0.0004116826,0.0002749012,0.0004057563,0.001311798,0.0008116876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005047125,"about_ca_system_score_gemma":0.0004342984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001781784,"about_ca_topic_score_gemma":0.003482204,"domain_scores_codex":[0.9996535,0.00003491168,0.00005303299,0.00005888344,0.00009790531,0.0001017419],"domain_scores_gemma":[0.9997384,0.00003815436,0.00006086273,0.00002981007,0.00001699149,0.0001156554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006761587,0.00003252339,0.0000717487,0.00002225785,0.000004870144,0.00005296203,0.000009838449,0.00007033519,0.9986091,0.0001555142,0.00005628087,0.0008470038],"study_design_scores_gemma":[0.00002645827,0.00008525851,0.001980413,0.000004514831,0.00001503266,0.0001437064,0.00002530528,0.0009573101,0.9946196,0.0000456794,0.002092184,0.000004444903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918714,0.0009808308,0.00255383,0.0002701688,0.0001005095,0.00004747318,0.000746528,0.0003240743,0.003105351],"genre_scores_gemma":[0.9922069,0.0005163716,0.001510199,0.00006863585,0.00001912526,0.00003097094,0.0003807574,0.00008318748,0.005183904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002440201,"threshold_uncertainty_score":0.008163333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005942601879896261,"score_gpt":0.1990093731824913,"score_spread":0.193066771302595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}