{"id":"W2911732523","doi":"10.1016/j.virol.2019.02.008","title":"Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers","year":2019,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"Canadian Institutes of Health Research; Simon Fraser University; Michael Smith Health Research BC","keywords":"NFAT; Biology; T-cell receptor; Transcription factor; Signal transduction; Allele; Downregulation and upregulation; Cell biology; T cell; Gene; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001629953,0.0001362637,0.0003981128,0.0001703692,0.00003489104,0.000004543296,0.0001334138,0.0002672523,0.002799574],"category_scores_gemma":[0.00002729846,0.00011649,0.00008451893,0.00007806213,0.00008952793,0.00007148052,0.00005727267,0.0001953351,0.002946407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004734314,"about_ca_system_score_gemma":0.00003991919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123941,"about_ca_topic_score_gemma":0.0001280294,"domain_scores_codex":[0.9987288,0.0002628689,0.0003124858,0.0002983453,0.00003342532,0.0003641212],"domain_scores_gemma":[0.9993242,0.0002680639,0.000102884,0.000247219,0.00003407338,0.00002355853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001030886,0.0001405413,0.07604653,0.000005318544,0.0002582989,0.00001016104,0.0006035119,0.0002390148,0.9191638,0.0001233462,0.0001397122,0.002238922],"study_design_scores_gemma":[0.03106926,0.002031249,0.740562,0.00007614997,0.0001057016,0.00003290235,0.0005875896,0.002186057,0.2140703,0.005038604,0.003725352,0.0005148549],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958434,0.00216467,0.0001440644,0.0005604075,0.0001676075,0.0003541629,0.000203768,0.00002129194,0.0005407042],"genre_scores_gemma":[0.9987909,0.00009005988,0.00006265983,0.0001287657,0.00001364596,0.00002159375,0.0002817487,0.00001120013,0.0005994331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7050934,"threshold_uncertainty_score":0.998112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009752231675689702,"score_gpt":0.235338953827711,"score_spread":0.2255867221520213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}