{"id":"W2911750380","doi":"10.1002/jimd.12070","title":"Hepatic glutamine synthetase augmentation enhances ammonia detoxification","year":2019,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Institute of Genetics; Horizon 2020 Framework Programme; National Institutes of Health; National Institute of Neurological Disorders and Stroke; H2020 European Research Council; Fondazione Telethon; Audentes Therapeutics","keywords":"Hyperammonemia; Glutamine synthetase; Urea cycle; Internal medicine; Glutamine; Endocrinology; Ornithine transcarbamylase; Carbamoyl phosphate synthetase; Detoxification (alternative medicine); Hepatic encephalopathy; Biology; Downregulation and upregulation; Chemistry; Biochemistry; Enzyme; Medicine; Arginine; Pathology; Cirrhosis; Gene; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174938,0.0003898004,0.0003204403,0.0002005235,0.00007226502,0.0002562846,0.0001588992,0.0001990791,0.001198907],"category_scores_gemma":[0.00009123106,0.0000807851,0.0001649912,0.0001138976,0.0002688512,0.0001572274,0.0001947314,0.0004705545,0.0001576248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092882,"about_ca_system_score_gemma":0.0001872267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003586181,"about_ca_topic_score_gemma":0.0006378632,"domain_scores_codex":[0.9998884,0.00002429854,0.000009237226,0.00002695144,0.0000257207,0.00002536576],"domain_scores_gemma":[0.9999059,0.00001448086,0.00002997587,0.00001129259,0.000008216403,0.00003012098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003147935,0.00005266596,0.0001237035,0.00003531047,0.000004861494,0.0000340581,0.000006474994,0.0000630673,0.9974022,0.00008561894,0.00002966653,0.001847637],"study_design_scores_gemma":[0.00003824166,0.001143266,0.001073046,0.000004539887,0.00001965019,0.0001139574,0.0000115854,0.0004769611,0.9955848,0.00003680752,0.001493843,0.000003195288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955258,0.000798183,0.002143048,0.00009324952,0.00004186998,0.00002919594,0.0001367837,0.0001466509,0.001085128],"genre_scores_gemma":[0.9959096,0.0005983876,0.001451705,0.00003727252,0.00001352598,0.00002152162,0.0001846274,0.0000168815,0.001766411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198907,"threshold_uncertainty_score":0.004010797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004889368988555859,"score_gpt":0.2397941790617262,"score_spread":0.2349048100731704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}