{"id":"W2911762019","doi":"10.1016/j.ejca.2018.12.029","title":"Safety and efficacy of durvalumab in patients with head and neck squamous cell carcinoma: results from a phase I/II expansion cohort","year":2019,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"MedImmune","keywords":"Durvalumab; Medicine; Head and neck; Cohort; Head and neck squamous-cell carcinoma; Basal cell; Oncology; Carcinoma; Internal medicine; Head and neck cancer; Surgery; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003197595,0.0001285942,0.0004903038,0.00008306801,0.00003692571,0.00000532558,0.00004839309,0.00001735323,0.00002776812],"category_scores_gemma":[0.00004660667,0.00008770984,0.00003441903,0.00009159109,0.00005873791,0.00007428049,0.00004757032,0.0002007198,0.000001300997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005929608,"about_ca_system_score_gemma":0.0001000748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001930745,"about_ca_topic_score_gemma":0.00004082774,"domain_scores_codex":[0.9987519,0.0001054496,0.0005237786,0.0001816767,0.0002957113,0.0001414837],"domain_scores_gemma":[0.9991676,0.00006714671,0.0003123196,0.0001452664,0.0001825689,0.0001251046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03253032,0.0006580883,0.9249687,0.00007201323,0.00005863146,0.0001289895,0.003935062,0.00002474954,0.001052129,4.518735e-7,0.0005502579,0.03602061],"study_design_scores_gemma":[0.07359508,0.006838293,0.9149866,0.0005792387,0.0000972198,0.000007100081,0.00009626897,0.00001374436,0.0004805468,3.188183e-7,0.003217755,0.00008784078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992985,0.003737691,0.000002414829,0.000253511,0.0001309007,0.0002497553,0.00005967556,0.000003250849,0.002577848],"genre_scores_gemma":[0.9990143,0.0004379641,0.0001213552,0.00009810468,0.00008801103,3.96742e-7,0.000006023733,0.0000220613,0.0002117373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04106476,"threshold_uncertainty_score":0.3576703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173302919513114,"score_gpt":0.2638317348907226,"score_spread":0.2520987056955915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}