{"id":"W2911775882","doi":"10.1016/j.bpj.2018.11.2908","title":"PKC Activation Decreases Kv1.5 Protein Expression through Accelerating Endocytic Channel Degradation","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre","funders":"","keywords":"Lactacystin; Protein kinase C; Cell biology; Chemistry; HEK 293 cells; Patch clamp; Immunoprecipitation; Molecular biology; Biology; Endocrinology; Phosphorylation; Receptor; Proteasome; Biochemistry; Proteasome inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000314569,0.0005109025,0.0005293823,0.0002128439,0.0003090099,0.0006913313,0.0002809415,0.0005368922,0.005565336],"category_scores_gemma":[0.0004649675,0.0002729508,0.000602892,0.0002006052,0.000359803,0.0006768484,0.0002478574,0.001493039,0.001396732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006210142,"about_ca_system_score_gemma":0.0007102124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007955013,"about_ca_topic_score_gemma":0.0007523743,"domain_scores_codex":[0.9995623,0.00005386276,0.00005957512,0.00009276372,0.00006962766,0.0001618373],"domain_scores_gemma":[0.999652,0.00005209622,0.0001026417,0.00006037506,0.00004719891,0.00008571555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003080734,0.0002666841,0.0004282382,0.0001454364,0.00003103292,0.00009307102,0.00002346906,0.00008731498,0.9915216,0.0002480822,0.000366104,0.003708108],"study_design_scores_gemma":[0.0002431768,0.000782014,0.006318353,0.00001893847,0.00006458332,0.0003724457,0.00006186255,0.0007080043,0.9883356,0.0001186216,0.002965937,0.00001059974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871926,0.003920165,0.003906539,0.0008395438,0.0006787136,0.0000675189,0.0007924243,0.0002421237,0.00236041],"genre_scores_gemma":[0.9882268,0.002530963,0.002232497,0.0002158562,0.000116709,0.00007068588,0.0007516903,0.00005453781,0.005800229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005565336,"threshold_uncertainty_score":0.01861793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371994716097989,"score_gpt":0.2758990107230482,"score_spread":0.2521790635620683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}