{"id":"W2911855056","doi":"10.1002/chin.200412132","title":"Design, Synthesis and Biological Activity of Novel Dimethyl‐{2‐[6‐substituted‐indol‐1‐yl]‐ethyl}‐amine as Potent, Selective, and Orally‐Bioavailable 5‐HT<sub>1D</sub> Agonists.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cantox Health Sciences International","funders":"","keywords":"Chemistry; Bioavailability; Amine gas treating; Orally active; Stereochemistry; Combinatorial chemistry; Pharmacology; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006800924,0.0004003248,0.0006058132,0.00006634377,0.0001857797,0.00006413672,0.0002390641,0.0005729078,0.0002045246],"category_scores_gemma":[0.002394645,0.0002971363,0.0001137372,0.0002461079,0.0005104237,0.0002311574,0.0001810362,0.0002875317,0.00001854523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712809,"about_ca_system_score_gemma":0.0001549449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108985,"about_ca_topic_score_gemma":0.00000755433,"domain_scores_codex":[0.99819,0.000006785334,0.000453781,0.0005882109,0.0003049343,0.0004563304],"domain_scores_gemma":[0.9981055,0.0006763114,0.0005191358,0.0003188484,0.0001791964,0.0002010241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002977111,0.0002962369,0.0006203919,0.0001092716,0.00008732783,0.000003696884,0.0000793286,0.000005335822,0.8953263,0.00005543355,0.00004351389,0.1030755],"study_design_scores_gemma":[0.001099417,0.000137302,0.006516478,0.0001148175,0.00008157094,0.00004761659,0.00008075173,0.00009627001,0.9908429,0.000388984,0.0001953507,0.0003985229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982359,0.0004288137,0.0001760542,0.0001635983,0.00003031791,0.0002395634,0.00004397954,0.00009994851,0.01645873],"genre_scores_gemma":[0.9976577,0.0007299028,0.001165944,0.00006536629,0.00007757309,0.00007624256,0.00003153588,0.00002038489,0.0001754011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.102677,"threshold_uncertainty_score":0.9999481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04960163656200686,"score_gpt":0.2596858909688798,"score_spread":0.210084254406873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}