{"id":"W2911855056","doi":"10.1002/chin.200412132","title":"Design, Synthesis and Biological Activity of Novel Dimethyl‐{2‐[6‐substituted‐indol‐1‐yl]‐ethyl}‐amine as Potent, Selective, and Orally‐Bioavailable 5‐HT<sub>1D</sub> Agonists.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cantox Health Sciences International","funders":"","keywords":"Chemistry; Bioavailability; Amine gas treating; Orally active; Stereochemistry; Combinatorial chemistry; Pharmacology; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469362,0.0004975202,0.0003396215,0.0001615135,0.0001708589,0.0003000108,0.0005391144,0.0003619123,0.003806468],"category_scores_gemma":[0.0001190008,0.0002793547,0.0002044779,0.0001222158,0.0001765104,0.0002733344,0.0001503813,0.0005620881,0.001582032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004560007,"about_ca_system_score_gemma":0.0003806652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005895846,"about_ca_topic_score_gemma":0.002195579,"domain_scores_codex":[0.9999285,0.00001376206,0.000006486252,0.00001548903,0.00001614152,0.00001971275],"domain_scores_gemma":[0.9999653,0.000003649486,0.00001080356,0.000003855567,0.000006986592,0.000009284995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008384051,0.0003143167,0.0001049671,0.0002494551,0.00003056313,0.0002206065,0.00004058254,0.001152335,0.9667413,0.0009478849,0.000895664,0.02846386],"study_design_scores_gemma":[0.000515022,0.002880995,0.001153951,0.00002175216,0.00007713452,0.0008363349,0.00002321675,0.001555258,0.9658936,0.0001679995,0.02685144,0.00002333035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9231651,0.01642455,0.02688862,0.0007520747,0.000207871,0.001463348,0.002498379,0.0005455201,0.02805446],"genre_scores_gemma":[0.9502313,0.007664266,0.01961319,0.0003307512,0.00005385333,0.00039313,0.002449938,0.00006031874,0.01920313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003806468,"threshold_uncertainty_score":0.01273394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04960163656200686,"score_gpt":0.2596858909688798,"score_spread":0.210084254406873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}