{"id":"W2911855642","doi":"10.1016/j.bmcl.2019.01.022","title":"Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"Consejo Nacional de Ciencia y Tecnología; Université de Montréal; Concordia University; Réseau Québécois de Recherche sur les Médicaments; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Methyltransferase; DNMT1; Chemistry; DNA methylation; Methylation; Epigenetics; Demethylation; Gene silencing; DNA methyltransferase; DNA demethylation; DNA; Molecular biology; Gene; Biochemistry; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546697,0.0004370523,0.0004324573,0.0004079363,0.0002645368,0.0001868444,0.0006373063,0.0003269874,0.003399212],"category_scores_gemma":[0.0002207158,0.00016885,0.0003089595,0.0005948237,0.0001169672,0.0002347805,0.00026938,0.0004974422,0.001494771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254231,"about_ca_system_score_gemma":0.0006721945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451121,"about_ca_topic_score_gemma":0.001637707,"domain_scores_codex":[0.9998837,0.00001258889,0.000015522,0.00001440467,0.00003570346,0.0000380869],"domain_scores_gemma":[0.9999337,0.000005991293,0.00001163175,0.00001443195,0.00001586031,0.00001836873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007670782,0.0003446114,0.0002790328,0.0002324413,0.00004522232,0.0004643655,0.00006373308,0.001650693,0.9618006,0.0008561242,0.0009244664,0.03257155],"study_design_scores_gemma":[0.0001693144,0.001223204,0.0007630847,0.000009891997,0.00006022975,0.0002809034,0.0000223454,0.0006327018,0.9857781,0.0001422046,0.01090079,0.0000171852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686009,0.002611107,0.008089617,0.0002407,0.00009166051,0.0005440381,0.003902529,0.0002746127,0.01564485],"genre_scores_gemma":[0.9772585,0.001757213,0.008784268,0.00008872685,0.00001843541,0.0003279947,0.003509662,0.00004785824,0.008207372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003399212,"threshold_uncertainty_score":0.01137155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105869790284979,"score_gpt":0.2366489907331972,"score_spread":0.2260620117046993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}