{"id":"W2911900547","doi":"10.1016/j.bpg.2019.02.005","title":"Targeting anti-fibrotic pathways in Crohn’s disease – The final frontier?","year":2019,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; University of Calgary","funders":"Janssen Biotech; Takeda Oncology; Eli Lilly and Company; Shire; Leona M. and Harry B. Helmsley Charitable Trust; AbbVie; Alzheimer Society of B.C.; Samsung; UCB; Celgene; Gilead Sciences; GlaxoSmithKline; Pfizer; Allergan","keywords":"Fibrosis; Crohn's disease; Medicine; Disease; Inflammation; Pathophysiology; Inflammatory bowel disease; Intensive care medicine; Bioinformatics; Immunology; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001393502,0.0009035467,0.002197107,0.001240024,0.0002471692,0.001656117,0.001189047,0.001928181,0.004446739],"category_scores_gemma":[0.001383158,0.0002933787,0.0005968212,0.001089268,0.0008014563,0.002121659,0.0009411169,0.004249156,0.002489819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006691311,"about_ca_system_score_gemma":0.001387185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008159159,"about_ca_topic_score_gemma":0.002237552,"domain_scores_codex":[0.9996809,0.00008082855,0.00003384514,0.00004513199,0.0001079663,0.00005139971],"domain_scores_gemma":[0.9994051,0.0002904472,0.00006676999,0.0000187033,0.00014298,0.00007596962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002814415,0.0001105011,0.000136374,0.01351185,0.0001251734,0.0001711592,0.00004309819,0.0003550711,0.001663229,0.006190017,0.06435739,0.9130547],"study_design_scores_gemma":[0.0001376383,0.0002240008,0.0005038062,0.006484213,0.0001867603,0.0007051218,0.00007228211,0.0001554063,0.0003678119,0.004983053,0.9861532,0.00002662538],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004564193,0.9981921,0.00009597604,0.0009504551,0.0003559002,0.000002521884,0.0000103821,0.000006894582,0.0003401824],"genre_scores_gemma":[0.0005483367,0.9974147,0.0001944907,0.0009470662,0.0004645323,0.000006378666,0.00002325076,0.000001962924,0.0003991727],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004446739,"threshold_uncertainty_score":0.01487583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.167653898805059,"score_gpt":0.460700965816388,"score_spread":0.293047067011329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}