{"id":"W2911912139","doi":"10.1093/ecco-jcc/jjy222.157","title":"P033 Periostin regulates ER-stress mediated intestinal subepithelial myofibroblasts function to promote fibrosis in Crohn’s disease","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Periostin; Matricellular protein; Myofibroblast; Unfolded protein response; Cancer research; Extracellular matrix; Western blot; Endoplasmic reticulum; Crohn's disease; Fibrosis; Vimentin; Biology; Chemistry; Pathology; Immunology; Molecular biology; Medicine; Cell biology; Immunohistochemistry; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154647,0.0002749822,0.000294963,0.0002492228,0.0002676685,0.0003732866,0.000164016,0.0004838117,0.00285817],"category_scores_gemma":[0.0001321402,0.000160911,0.0004606935,0.0001915958,0.0003019641,0.0001535249,0.0002258923,0.0009637705,0.00105382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596088,"about_ca_system_score_gemma":0.0002041949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003809558,"about_ca_topic_score_gemma":0.0005407329,"domain_scores_codex":[0.9998385,0.00002133693,0.0000126558,0.00003139231,0.00004282689,0.0000533062],"domain_scores_gemma":[0.9998925,0.000008477284,0.00003013356,0.000007072358,0.00001266592,0.00004921198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00157786,0.0001110425,0.001909146,0.0001589662,0.0000221361,0.0007452883,0.00005723079,0.00008977841,0.9887427,0.0001853461,0.0007847759,0.005615659],"study_design_scores_gemma":[0.0008465252,0.003101402,0.231243,0.0001186493,0.0002494512,0.007299404,0.0005975219,0.003216527,0.7166877,0.0009259589,0.03566079,0.0000530299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884536,0.004344695,0.001862167,0.0005291579,0.0001841205,0.00003604281,0.0008281342,0.0002396541,0.003522391],"genre_scores_gemma":[0.9927649,0.001112339,0.0008486729,0.0002669749,0.00002340295,0.00006022863,0.0008076872,0.00003494896,0.004080849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00285817,"threshold_uncertainty_score":0.009561479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004264286486650001,"score_gpt":0.2122432959173909,"score_spread":0.2079790094307409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}