{"id":"W2911915385","doi":"10.1016/j.csbj.2019.01.009","title":"Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment","year":2019,"lang":"en","type":"review","venue":"Computational and Structural Biotechnology Journal","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministry of Health, British Columbia","keywords":"XIAP; Inhibitor of apoptosis; Caspase; Apoptosis; Cell biology; Cancer research; Cancer cell; Biology; Cancer; Chemistry; Programmed cell death; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037735,0.0001924929,0.0005240301,0.0001500204,0.00007701085,0.000009280675,0.0001431076,0.0004176187,0.000008119567],"category_scores_gemma":[0.00001592565,0.0001064607,0.0001725606,0.0001303868,0.0001562936,0.000003230507,0.00007799426,0.0002043109,2.446582e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004000286,"about_ca_system_score_gemma":0.0001891997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001376394,"about_ca_topic_score_gemma":0.000005032306,"domain_scores_codex":[0.9990078,0.0000686867,0.0004912198,0.0001976223,0.0001036369,0.0001309971],"domain_scores_gemma":[0.999253,0.00002490303,0.0005277729,0.0001036189,0.00006841959,0.00002223561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002486327,0.00002143441,0.00005801336,0.0009129859,0.000239444,0.00000120893,0.00003638434,0.001642508,0.01222729,0.0006859483,0.00002484301,0.9841251],"study_design_scores_gemma":[0.006081024,0.005392035,0.001099272,0.01141798,0.001930272,0.002005472,0.000537603,0.005616082,0.06043636,0.01523473,0.8880628,0.002186371],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05353534,0.9450518,0.000514286,0.0001628768,0.0002189739,0.0004410316,0.00006922765,0.000003007812,0.00000338184],"genre_scores_gemma":[0.03670765,0.9616331,0.001356788,0.000005707745,0.000135837,0.00001482886,0.0001038794,0.00001258173,0.00002965572],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9819387,"threshold_uncertainty_score":0.434134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936545569309535,"score_gpt":0.2938262477594779,"score_spread":0.2744607920663826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}