{"id":"W2911934590","doi":"10.1111/acel.12897","title":"Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Cancer Institute; National Institute on Aging; National Institutes of Health","keywords":"dNaM; Biology; DNA methylation; Haematopoiesis; Hematopoietic stem cell transplantation; Epigenetics; Immunology; Stem cell; Transplantation; CpG site; CD34; Cancer; Internal medicine; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852472,0.0002043366,0.0001977258,0.00008282434,0.00005137691,0.00003296156,0.0002091972,0.000154959,0.00009972086],"category_scores_gemma":[0.000002484506,0.000172917,0.00009453359,0.0001289188,0.00003403455,0.000003421308,0.00005595959,0.0001379274,0.0001302737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001652748,"about_ca_system_score_gemma":0.00003924585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346851,"about_ca_topic_score_gemma":0.00006079347,"domain_scores_codex":[0.9986575,0.00007364753,0.0002914184,0.0004838343,0.0001476048,0.0003459428],"domain_scores_gemma":[0.999348,0.00001151712,0.00007867524,0.0004507467,0.00003344204,0.00007766228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001109723,0.0001023885,0.008871214,0.0001725342,0.000006260726,0.00001481071,0.0004189634,0.0001474953,0.9897387,0.000002671047,0.0001035871,0.0004102992],"study_design_scores_gemma":[0.0008565502,0.0001754794,0.002975248,0.00004890131,0.00001497712,0.000001180984,0.0000532861,0.00007630426,0.9851279,0.00007243419,0.01031703,0.0002807624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849864,0.00134412,0.0002876019,0.00004827271,0.0001424166,0.0003713994,0.000007705985,0.00001518256,0.01279688],"genre_scores_gemma":[0.9910294,0.0004438851,0.0003304537,0.0001731564,0.00006311496,0.00001250848,0.00007794356,0.00004091576,0.007828619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021345,"threshold_uncertainty_score":0.7051351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007997496894785764,"score_gpt":0.2276573686827953,"score_spread":0.2196598717880096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}