{"id":"W2911934590","doi":"10.1111/acel.12897","title":"Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Cancer Institute; National Institute on Aging; National Institutes of Health","keywords":"dNaM; Biology; DNA methylation; Haematopoiesis; Hematopoietic stem cell transplantation; Epigenetics; Immunology; Stem cell; Transplantation; CpG site; CD34; Cancer; Internal medicine; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288267,0.0001213053,0.0001825916,0.0003982408,0.0001443055,0.000242832,0.0001141996,0.0001273656,0.0007983381],"category_scores_gemma":[0.0003572326,0.00008888347,0.0001097486,0.0003513165,0.0001844728,0.0001857928,0.000214796,0.0002413064,0.0002043104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130044,"about_ca_system_score_gemma":0.0001081553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003171267,"about_ca_topic_score_gemma":0.0004983033,"domain_scores_codex":[0.9998673,0.00001935479,0.00001188279,0.00004797868,0.00003970553,0.00001369186],"domain_scores_gemma":[0.999762,0.00004357248,0.0001087287,0.00003279698,0.0000303941,0.00002252382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001871502,0.0000140141,0.03636247,0.00004288422,0.00003085269,0.00008796359,0.0001175219,0.00009504631,0.9510245,0.0002128373,0.00005062513,0.01177407],"study_design_scores_gemma":[0.000005550206,0.0003984867,0.5707365,0.000009276021,0.00005531409,0.001174932,0.0001236621,0.0007273704,0.42251,0.0003848285,0.00386052,0.00001361361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881423,0.002842407,0.007215437,0.00004038377,0.00001658485,0.00001440645,0.0006655926,0.00003752718,0.001025271],"genre_scores_gemma":[0.996482,0.0007527167,0.001642109,0.00002373629,0.00001263308,0.0000132349,0.0004373754,0.000009427983,0.0006267423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007983381,"threshold_uncertainty_score":0.002670705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007997496894785764,"score_gpt":0.2276573686827953,"score_spread":0.2196598717880096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}