{"id":"W2911986230","doi":"10.1158/1538-7445.prca2017-a087","title":"Abstract A087: Enzalutamide-induced hypoxia attenuates response and promotes resistance to enzalutamide in preclinical models of prostate cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Enzalutamide; LNCaP; Prostate cancer; Angiogenesis; Cancer research; Androgen receptor; Hypoxia (environmental); In vivo; Cancer cell; Downregulation and upregulation; Medicine; Cancer; Chemistry; Biology; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761944,0.000539053,0.0005513371,0.0003628364,0.0001833965,0.0002769798,0.0003996656,0.0003253496,0.002690209],"category_scores_gemma":[0.00008287303,0.0001962028,0.0003144433,0.0002452862,0.0002470149,0.0002220047,0.0001080756,0.001218265,0.0004401858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004569582,"about_ca_system_score_gemma":0.0005509733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094531,"about_ca_topic_score_gemma":0.004106457,"domain_scores_codex":[0.9997951,0.00003835075,0.00001452333,0.00003244345,0.00004877512,0.00007075274],"domain_scores_gemma":[0.9998957,0.000010042,0.00002373251,0.00001129764,0.00001454151,0.00004467423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002434648,0.001013164,0.0002303297,0.00007142832,0.00002668473,0.00005421495,0.00001625574,0.0002543842,0.9912616,0.0001004888,0.0004286398,0.004108139],"study_design_scores_gemma":[0.0003416987,0.01288834,0.005144285,0.00001133612,0.0000522203,0.0001990093,0.00003387886,0.001622187,0.9764993,0.00004844691,0.003148538,0.00001083668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937813,0.001166846,0.001131922,0.0001792823,0.00008521492,0.0001201492,0.000998046,0.0002576628,0.00227969],"genre_scores_gemma":[0.9869798,0.0009551955,0.002312222,0.0001144866,0.00003484472,0.0002240317,0.001740409,0.0000561073,0.007582968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002690209,"threshold_uncertainty_score":0.008999586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08902120461178369,"score_gpt":0.4159187538479698,"score_spread":0.3268975492361861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}