{"id":"W2911986426","doi":"10.1182/blood-2018-99-118889","title":"AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network","funders":"","keywords":"Myelofibrosis; Myeloid; Myeloid leukemia; Biology; clone (Java method); Cancer research; CD34; Stem cell; Bone marrow; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012816,0.0001196554,0.00020088,0.00058428,0.0003673585,0.0004288424,0.0001673174,0.000319771,0.001226527],"category_scores_gemma":[0.0007806687,0.0001396214,0.0001172113,0.0002427718,0.0001700147,0.0001771812,0.0002396101,0.0003237342,0.0002461066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932037,"about_ca_system_score_gemma":0.0001648654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527446,"about_ca_topic_score_gemma":0.001628557,"domain_scores_codex":[0.9998653,0.0000159201,0.00001118303,0.00003989793,0.00002621021,0.000041414],"domain_scores_gemma":[0.9995888,0.00009291316,0.0001202613,0.00002891,0.00004650931,0.0001226491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000787241,0.0001268671,0.9550706,0.00001204618,0.00001790718,0.004566413,0.0004838762,0.0001286512,0.02996042,0.0001106849,0.0001085278,0.00862682],"study_design_scores_gemma":[0.00003069749,0.0007771355,0.9773952,0.000008257454,0.00002570376,0.01171235,0.000336296,0.0004864414,0.008022454,0.00009765509,0.001097645,0.0000100823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996634,0.00005453017,0.00004907376,0.000005032653,9.059438e-7,0.000005354402,0.00005097309,0.000002857773,0.0001678371],"genre_scores_gemma":[0.9995582,0.00002349891,0.00007623572,0.000009734071,0.000002174904,0.000004892844,0.0001378564,0.000001480161,0.0001860558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527446,"threshold_uncertainty_score":0.004103124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146227057479416,"score_gpt":0.2444086326919608,"score_spread":0.2329463621171667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}