{"id":"W2912014539","doi":"10.4049/jimmunol.1801477","title":"MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Heart, Lung, and Blood Institute","keywords":"Gene knockdown; MAPK/ERK pathway; GLUT1; Kinase; Downregulation and upregulation; Cell biology; Proinflammatory cytokine; TLR4; Glucose transporter; Internal medicine; Biology; Chemistry; Endocrinology; Signal transduction; Inflammation; Insulin; Medicine; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071711,0.0004848038,0.0002166302,0.0001694477,0.0001825242,0.0002419236,0.0001944967,0.0001456944,0.001684101],"category_scores_gemma":[0.00007565228,0.0001397072,0.0002223924,0.00009917126,0.000192244,0.0001396616,0.000160031,0.0004339563,0.0004776407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615397,"about_ca_system_score_gemma":0.0001757777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004834462,"about_ca_topic_score_gemma":0.0005864212,"domain_scores_codex":[0.9998722,0.00002050529,0.00001308475,0.0000269095,0.00002887807,0.00003839884],"domain_scores_gemma":[0.9999267,0.000009094919,0.00002011839,0.000006460885,0.00001262863,0.00002497093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001943218,0.0000310239,0.000150363,0.00006260573,0.000005581984,0.00002380056,0.000009391804,0.00005239317,0.9988297,0.00006004902,0.00007749665,0.0005031909],"study_design_scores_gemma":[0.00003050003,0.0001542261,0.002728439,0.00000621903,0.00001575429,0.0001348223,0.00002270367,0.001240276,0.993507,0.00002689929,0.002128346,0.000004635459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932724,0.001555134,0.002681645,0.0001541552,0.00007330652,0.00003330375,0.0007280021,0.0001433985,0.001358626],"genre_scores_gemma":[0.9951022,0.0005865078,0.001432471,0.00006308211,0.00001364029,0.00004695359,0.0006457427,0.00002663842,0.002082773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684101,"threshold_uncertainty_score":0.005633891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008752400287532864,"score_gpt":0.2352189368183471,"score_spread":0.2264665365308143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}