{"id":"W2912042406","doi":"10.3390/ijms20061394","title":"Differential Methylation in APOE (Chr19; Exon Four; from 44,909,188 to 44,909,373/hg38) and Increased Apolipoprotein E Plasma Levels in Subjects with Mild Cognitive Impairment","year":2019,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Langley Research Center; International Brain Research Organization; Dirección de Investigación, Universidad Nacional de Colombia; Houston Methodist Hospital; Institute of Genetics; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Apolipoprotein E; Methylation; Internal medicine; DNA methylation; CpG site; Oncology; Endocrinology; Medicine; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309344,0.0001873662,0.0001540193,0.0005492996,0.0002283366,0.0002440024,0.0001483631,0.000215866,0.002126657],"category_scores_gemma":[0.0005422162,0.0001066582,0.0001069737,0.000405521,0.0001742846,0.00006495522,0.0001737589,0.0001415958,0.0001468656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000312648,"about_ca_system_score_gemma":0.0001801968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01975718,"about_ca_topic_score_gemma":0.0202841,"domain_scores_codex":[0.9998933,0.00001941589,0.000009221515,0.00004122208,0.00001466539,0.00002221816],"domain_scores_gemma":[0.9997768,0.00003813004,0.0001100042,0.00001222179,0.00002366309,0.00003916156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004992473,0.00002963308,0.9893883,0.00003319403,0.00005180744,0.0001749245,0.0001517196,0.00002920395,0.00633505,0.00001982076,0.00006181091,0.003225318],"study_design_scores_gemma":[0.000003114038,0.00002391607,0.9993994,0.000002266174,0.00001358281,0.0001941074,0.00004332897,0.00004207196,0.0002097868,0.00001014835,0.00005706397,0.000001163749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993328,0.0001903706,0.00007094078,0.00001576451,0.000001487711,0.000003877735,0.0001742832,0.000002933241,0.0002074674],"genre_scores_gemma":[0.9996938,0.00003870705,0.00006340407,0.000005488419,0.000001288738,0.000002147552,0.00009259216,8.265838e-7,0.000101735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01975718,"threshold_uncertainty_score":0.03928435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424835704361294,"score_gpt":0.3183967889634753,"score_spread":0.2941484319198624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}