{"id":"W2912043817","doi":"10.3389/fcvm.2018.00195","title":"Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities","year":2019,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Mitochondrial fission; Internal medicine; Ventricle; Pulmonary hypertension; Medicine; Cardiology; Pulmonary artery; Pulmonary wedge pressure; Ventricular pressure; Pressure overload; Endocrinology; Heart failure; Mitochondrion; Blood pressure; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005887609,0.0004360082,0.001039501,0.0005665554,0.00005820475,0.00001732757,0.0002455899,0.000472411,0.00006046858],"category_scores_gemma":[0.0003774088,0.0003814575,0.0003075576,0.0004575809,0.0002532107,0.00003644313,0.0002050301,0.0003575579,0.00000643295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349448,"about_ca_system_score_gemma":0.00009533884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006584707,"about_ca_topic_score_gemma":0.00004845589,"domain_scores_codex":[0.9968342,0.0003368775,0.0007041864,0.0009985234,0.0005299424,0.0005962781],"domain_scores_gemma":[0.9988814,0.00004666654,0.0001143741,0.0006848836,0.00005821561,0.0002144801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002959012,0.0006632864,0.09250909,0.0001880023,0.0003092655,0.001214619,0.0004456998,0.0003055912,0.8948992,0.00004502759,0.003959258,0.002501914],"study_design_scores_gemma":[0.1548727,0.008264573,0.2207706,0.003693042,0.001082466,0.003908687,0.03168831,0.008635765,0.2184002,0.0005651645,0.3417662,0.006352232],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450268,0.04690422,0.001149933,0.0001145249,0.005047532,0.001457139,0.00001721797,0.00002154963,0.0002610817],"genre_scores_gemma":[0.9920289,0.001150999,0.003286082,0.000342133,0.002055396,0.0002937727,0.0004997149,0.00007219823,0.0002708038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6764991,"threshold_uncertainty_score":0.9998637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007560663805611637,"score_gpt":0.2083126370330295,"score_spread":0.2007519732274179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}