{"id":"W2912043817","doi":"10.3389/fcvm.2018.00195","title":"Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities","year":2019,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Mitochondrial fission; Internal medicine; Ventricle; Pulmonary hypertension; Medicine; Cardiology; Pulmonary artery; Pulmonary wedge pressure; Ventricular pressure; Pressure overload; Endocrinology; Heart failure; Mitochondrion; Blood pressure; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816991,0.0006267921,0.0003442444,0.0004970208,0.0002290703,0.0002463759,0.0002522363,0.0004068724,0.002059402],"category_scores_gemma":[0.0001236012,0.0001990686,0.0003894833,0.0001638248,0.0007221234,0.0003335293,0.0002930676,0.0008744551,0.0002543843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992315,"about_ca_system_score_gemma":0.0002206979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003091275,"about_ca_topic_score_gemma":0.0004740149,"domain_scores_codex":[0.9998498,0.00001935956,0.00001503342,0.00004488301,0.00003200603,0.00003890336],"domain_scores_gemma":[0.999724,0.00002693672,0.00009600168,0.00003098376,0.00001479119,0.0001072594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002151906,0.0006508236,0.001774056,0.00006455237,0.00001676626,0.0005695312,0.00005670812,0.00004571759,0.9927304,0.0001437609,0.00007050785,0.001725157],"study_design_scores_gemma":[0.000619379,0.0112413,0.06091297,0.00002610089,0.0001187322,0.002829061,0.0002738138,0.001084658,0.9206653,0.0001929695,0.002010538,0.00002522593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984196,0.0003005094,0.0006662261,0.00004959485,0.00003076992,0.00002689053,0.0001335144,0.00004343043,0.0003294802],"genre_scores_gemma":[0.9960285,0.0004490614,0.0009763029,0.00005894433,0.00003729002,0.0001284627,0.000496743,0.0000169615,0.001807739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059402,"threshold_uncertainty_score":0.006889403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007560663805611637,"score_gpt":0.2083126370330295,"score_spread":0.2007519732274179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}