{"id":"W2912073579","doi":"10.1101/550699","title":"Immune Responses to Human Induced Pluripotent Stem Cells and their Derived Myogenic Progenitors Are Mediated by Different Mechanisms in Humanized Mice","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Induced pluripotent stem cell; Adoptive cell transfer; Reprogramming; Immune system; Progenitor cell; Biology; Immunology; Humanized mouse; Cell biology; Stem cell; Cell therapy; Cancer research; Embryonic stem cell; Cell; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009555612,0.0004701732,0.0003557373,0.0007961505,0.0001503501,0.0005834823,0.0002931095,0.0005973838,0.00373178],"category_scores_gemma":[0.0002190044,0.0002762206,0.0005079648,0.0002061766,0.0005850641,0.0003870372,0.0003294315,0.001199855,0.0007674269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389366,"about_ca_system_score_gemma":0.0002127912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001951147,"about_ca_topic_score_gemma":0.000222301,"domain_scores_codex":[0.9994276,0.000135855,0.00007639132,0.0001392277,0.0001488249,0.00007226346],"domain_scores_gemma":[0.9997454,0.00005261253,0.00008589099,0.00006285172,0.00001600042,0.00003714906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004791699,0.0001406426,0.0004166043,0.00007308782,0.00002262368,0.00009930847,0.00005898479,0.0001638784,0.9937377,0.0005775769,0.0001161329,0.004114287],"study_design_scores_gemma":[0.0001021896,0.001809315,0.005408959,0.00003833472,0.00006709743,0.0008640441,0.00008623733,0.00115681,0.9842775,0.0002852371,0.005893413,0.00001088133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720948,0.003023968,0.01885653,0.0003249757,0.000116915,0.0002195853,0.001278341,0.0003988846,0.003685961],"genre_scores_gemma":[0.979098,0.001714173,0.008192485,0.0002547023,0.0000332053,0.0003125938,0.001483143,0.0001026064,0.008809175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00373178,"threshold_uncertainty_score":0.01248407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613761515231578,"score_gpt":0.2303364881085305,"score_spread":0.2141988729562147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}