{"id":"W2912093892","doi":"10.1016/j.chemosphere.2019.01.169","title":"Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway","year":2019,"lang":"en","type":"article","venue":"Chemosphere","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; Nanjing University; National Natural Science Foundation of China","keywords":"Aryl hydrocarbon receptor; Genotoxicity; Chemistry; Reactive oxygen species; Oxidative stress; Transfection; Signal transduction; Molecular biology; Biochemistry; Gene; Biology; Toxicity; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828172,0.0004437076,0.0001983763,0.0003799247,0.0002149947,0.0002398476,0.000147648,0.0003225481,0.002825973],"category_scores_gemma":[0.0001708426,0.000214113,0.0003339148,0.000303958,0.0001703608,0.0001977233,0.0002893307,0.0003649145,0.000416223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410109,"about_ca_system_score_gemma":0.000281768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451432,"about_ca_topic_score_gemma":0.002608123,"domain_scores_codex":[0.9998307,0.00003513741,0.00001111899,0.00003259126,0.00004942897,0.00004100773],"domain_scores_gemma":[0.9998298,0.00002802702,0.00005913983,0.00002283029,0.00003512119,0.00002503329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006265756,0.00007415412,0.002498957,0.00007518186,0.00003749328,0.0001254501,0.00002306651,0.000141034,0.9938214,0.0001032027,0.0001543464,0.002319149],"study_design_scores_gemma":[0.00004121242,0.0009108012,0.0357382,0.000006740137,0.00005439298,0.0003168139,0.00007157012,0.0007431209,0.9598055,0.0002228603,0.002079275,0.000009483477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925089,0.00190757,0.002816502,0.0002778589,0.00007610829,0.00003468703,0.0007005357,0.00009391965,0.00158388],"genre_scores_gemma":[0.9956399,0.0009257696,0.0004571981,0.00006429093,0.00001140346,0.00001556262,0.0005651557,0.000007048185,0.002313573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825973,"threshold_uncertainty_score":0.009453833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005918503346721001,"score_gpt":0.1900388728843519,"score_spread":0.1841203695376309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}