{"id":"W2912166467","doi":"10.1016/j.antiviral.2019.02.005","title":"Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors","year":2019,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Hepatitis B virus; RNase H; Virology; DNA; Biology; Molecular biology; Cytotoxicity; Viral replication; DNA replication; Ribonuclease; RNA; RNase P; Chemistry; Virus; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004156112,0.000237984,0.0002410647,0.0001971873,0.0001139096,0.000194183,0.0002323749,0.0001948098,0.001608065],"category_scores_gemma":[0.000277734,0.0001218955,0.0002047149,0.0000969227,0.0001849347,0.0001858499,0.0001132025,0.0003135776,0.000251059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017514,"about_ca_system_score_gemma":0.0001738053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005519715,"about_ca_topic_score_gemma":0.0007738147,"domain_scores_codex":[0.9998192,0.00008508594,0.00001534397,0.00001525946,0.00002601241,0.00003913391],"domain_scores_gemma":[0.9998428,0.00006785781,0.00002952092,0.00001641771,0.00001624251,0.00002711773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005937714,0.0005266406,0.0006386506,0.0001804342,0.00003473374,0.0001035384,0.00006767986,0.0004505805,0.9708554,0.0004449167,0.0002144927,0.02054533],"study_design_scores_gemma":[0.0005605142,0.01245331,0.003936126,0.00001559225,0.00003472196,0.0002107115,0.00003468989,0.0009995177,0.9775944,0.00006900369,0.004079936,0.00001140296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821145,0.01107533,0.001799523,0.00014028,0.0001010655,0.00008130755,0.0001482681,0.00007511125,0.004464629],"genre_scores_gemma":[0.9944704,0.002142705,0.0009703597,0.00004532598,0.00004275462,0.00003280009,0.0001685594,0.000007149779,0.00211996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608065,"threshold_uncertainty_score":0.005379558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0396463608960163,"score_gpt":0.3570163981326019,"score_spread":0.3173700372365856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}