{"id":"W2912176519","doi":"10.1002/cbic.201900055","title":"Cover Feature: A Bioluminescent Ca<sup>2+</sup> Indicator Based on a Topological Variant of GCaMP6s (ChemBioChem 4/2019)","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioluminescence; Topology (electrical circuits); Chromophore; Luciferase; Cover (algebra); Fusion protein; Chemistry; Resonance (particle physics); Fusion; Physics; Biophysics; Biology; Biochemistry; Photochemistry; Gene; Atomic physics; Recombinant DNA; Mathematics; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001844209,0.001078925,0.0006916671,0.001006311,0.0004864965,0.0008277179,0.00131142,0.001511992,0.3198878],"category_scores_gemma":[0.0005134593,0.0006098941,0.0006204951,0.0005988111,0.0003261412,0.001278382,0.000589652,0.001747134,0.08348437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006703249,"about_ca_system_score_gemma":0.0002871107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004804259,"about_ca_topic_score_gemma":0.0007382266,"domain_scores_codex":[0.9997777,0.000007460826,0.000006585744,0.00004194088,0.0001169038,0.00004942527],"domain_scores_gemma":[0.9996784,0.00006226863,0.00003557215,0.00002633092,0.00006378019,0.0001337967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007314415,0.00009041838,0.0001383534,0.0004792465,0.00001741603,0.0005502612,0.00001720069,0.0002469307,0.2067114,0.002350315,0.735934,0.05273308],"study_design_scores_gemma":[0.0003005955,0.0004665675,0.002456488,0.00007107174,0.0000328268,0.00174076,0.00002297316,0.0027506,0.1230471,0.001269785,0.8677842,0.00005703912],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.0371435,0.01613225,0.04984144,0.02620418,0.05067639,0.001235456,0.04319604,0.04545524,0.7301154],"genre_scores_gemma":[0.1050268,0.007676812,0.0238868,0.007959763,0.008214273,0.0009754412,0.04086563,0.008361457,0.797033],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3198878,"threshold_uncertainty_score":0.9700974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00830077176362958,"score_gpt":0.2483871891632999,"score_spread":0.2400864173996703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}