{"id":"W2912229012","doi":"10.1080/1547691x.2018.1516014","title":"Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury","year":2019,"lang":"en","type":"article","venue":"Journal of Immunotoxicology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Amodiaquine; Macrophage; CCR2; Liver injury; Medicine; CCL2; Pharmacology; Cancer research; Inflammation; Immunology; Biology; Chemokine; Chloroquine; In vitro; Biochemistry; Chemokine receptor; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009132666,0.0001863026,0.0006031893,0.000531285,0.00003881682,0.000007445663,0.0002940258,0.0003522142,0.003976913],"category_scores_gemma":[0.00009042948,0.0001597256,0.0002253161,0.0001919971,0.00008278367,0.000211314,0.00009948913,0.0007717282,0.0005262571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769779,"about_ca_system_score_gemma":0.0001522428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007903238,"about_ca_topic_score_gemma":0.00001424432,"domain_scores_codex":[0.9977742,0.0005393447,0.001131538,0.0001696867,0.00007331337,0.0003119278],"domain_scores_gemma":[0.9983652,0.0001729744,0.0009349532,0.0002767754,0.0002290247,0.00002107255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001861849,0.0006397062,0.001906714,0.00003097532,0.0002256428,0.00001939187,0.001223156,0.00001244559,0.986617,0.0001573374,0.002384477,0.004921361],"study_design_scores_gemma":[0.004487434,0.004865598,0.01247399,0.0001374287,0.00004417323,0.0002742329,0.002277042,0.00000869335,0.9266016,0.00004234925,0.04860311,0.0001842896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875481,0.00244247,0.00002339416,0.0001533459,0.008347916,0.0004952354,0.000002182024,0.000008217022,0.0009791664],"genre_scores_gemma":[0.9960144,0.0004948272,0.00005539576,0.0003270486,0.00003526688,0.0000170479,0.00001064393,0.00001652905,0.003028847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06001528,"threshold_uncertainty_score":0.9969336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03189994025645634,"score_gpt":0.2814895320551692,"score_spread":0.2495895917987128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}