{"id":"W2912229014","doi":"10.1016/b978-0-12-813333-0.00014-7","title":"Optogenetics: Illuminating the Neural Circuits of Depression","year":2019,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Optogenetics; Neuroscience; Nucleus accumbens; Ventral tegmental area; Biological neural network; Prefrontal cortex; Hippocampus; Animal models of depression; Psychology; Premovement neuronal activity; Central nervous system; Antidepressant; Cognition; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003120125,0.00038328,0.0004502019,0.0001603728,0.0001859222,0.00006114499,0.001180317,0.0002859075,0.0003648669],"category_scores_gemma":[0.0001977433,0.0002724674,0.0002815887,0.00003007448,0.0004986809,0.00002874311,0.0005640704,0.0007291061,0.0001842178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004874834,"about_ca_system_score_gemma":0.0001762106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.463572e-7,"about_ca_topic_score_gemma":0.000003170363,"domain_scores_codex":[0.9972286,0.0001208273,0.0005079091,0.0006699874,0.001029778,0.0004428529],"domain_scores_gemma":[0.9978695,0.0004967057,0.0003598304,0.001016247,0.0001342919,0.0001234342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009175885,0.000007369737,0.00004825735,0.00009376042,0.00001170897,0.000008508862,0.0002410559,0.00001088945,0.1328803,0.0006690531,0.0000320298,0.8659879],"study_design_scores_gemma":[0.000343851,0.0001410358,0.00008130722,0.0003788389,0.00005378103,0.00003372262,0.00001428624,0.0004045326,0.5781824,0.001341329,0.4185401,0.0004848701],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.009492096,0.0009035186,0.000002582127,0.00001845331,0.0005998866,0.0009451948,0.00007573232,0.00002947232,0.987933],"genre_scores_gemma":[0.2889992,0.0001627213,0.0000211976,0.000178314,0.0001754091,0.00001906713,0.000004041111,0.00009394691,0.7103462],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.865503,"threshold_uncertainty_score":0.9999728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377557372657131,"score_gpt":0.2932328220216885,"score_spread":0.2494572482951172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}