{"id":"W2912229014","doi":"10.1016/b978-0-12-813333-0.00014-7","title":"Optogenetics: Illuminating the Neural Circuits of Depression","year":2019,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Optogenetics; Neuroscience; Nucleus accumbens; Ventral tegmental area; Biological neural network; Prefrontal cortex; Hippocampus; Animal models of depression; Psychology; Premovement neuronal activity; Central nervous system; Antidepressant; Cognition; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388705,0.0004219287,0.0002206709,0.0004796183,0.0002146134,0.001240538,0.0004741982,0.0009473049,0.01191895],"category_scores_gemma":[0.0001517795,0.0001708953,0.0001837982,0.000473571,0.0006885414,0.001164772,0.0004204864,0.001814329,0.004210724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005260334,"about_ca_system_score_gemma":0.0003625754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007635869,"about_ca_topic_score_gemma":0.002343518,"domain_scores_codex":[0.999959,0.000004569166,0.000001524021,0.000007693424,0.00002319164,0.000004000659],"domain_scores_gemma":[0.9999547,0.00002566881,0.000002845095,0.000003150591,0.000007407698,0.000006227868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000512623,0.00003953481,0.000149318,0.0004892965,0.00001626591,0.0001873876,0.0001637209,0.0007458715,0.02317467,0.2254196,0.1371079,0.6124551],"study_design_scores_gemma":[0.00001099098,0.00003309932,0.0004706131,0.0002882624,0.000009068101,0.0005323487,0.00008757215,0.0007729284,0.004408751,0.1262854,0.8670856,0.00001546165],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003923466,0.4825431,0.04779082,0.01568074,0.005543336,0.00003688881,0.0002158445,0.0003903821,0.4438754],"genre_scores_gemma":[0.03637282,0.3157802,0.02020979,0.005185816,0.003399021,0.00007679788,0.0001339255,0.0001704973,0.6186712],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01191895,"threshold_uncertainty_score":0.03987288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377557372657131,"score_gpt":0.2932328220216885,"score_spread":0.2494572482951172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}