{"id":"W2912247884","doi":"10.1074/jbc.ra119.007587","title":"Specificity of the chromophore-binding site in human cone opsins","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; Case Western Reserve University; Alcon Research Institute; Canadian Institute for Advanced Research; University of California, Irvine; Research to Prevent Blindness","keywords":"Opsin; Rhodopsin; Chromophore; Visual phototransduction; Retinaldehyde; Retinal; Biophysics; Chemistry; Photopigment; Photochemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407865,0.00007933185,0.0002172802,0.00002542974,0.00003751222,0.0000153633,0.0005126425,0.0001108599,0.0007909114],"category_scores_gemma":[0.0003632208,0.00004437435,0.0001267714,0.000215018,0.0002052722,0.000027244,0.0001481917,0.0004566541,0.00001182772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000648721,"about_ca_system_score_gemma":0.00004040558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002436106,"about_ca_topic_score_gemma":3.616622e-7,"domain_scores_codex":[0.9989477,0.00007639719,0.0003493881,0.0001415273,0.0002980188,0.0001869396],"domain_scores_gemma":[0.9993312,0.0001572633,0.0002359061,0.0001596567,0.00004909983,0.00006682226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004074866,0.00009078957,0.05319519,0.00001483689,0.000001806041,0.00001055534,0.00003217595,0.00001101388,0.9465203,0.000006610771,0.00004289326,0.00003302286],"study_design_scores_gemma":[0.0003335479,0.00009244218,0.0212239,0.00003926425,0.000001001457,0.00003829285,0.00003327293,0.0000149048,0.9775802,0.00008079786,0.0005082846,0.00005406908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952363,0.00005238261,0.000001042433,0.00004852601,0.00009286424,0.00006545678,0.00001729673,0.000002194347,0.004483909],"genre_scores_gemma":[0.9995604,0.00009284423,0.0000150002,0.00002939336,0.00007891619,4.560393e-7,6.001414e-7,0.000003756232,0.0002186404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0319713,"threshold_uncertainty_score":0.8659925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06928075631498885,"score_gpt":0.3220577615682194,"score_spread":0.2527770052532305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}