{"id":"W2912258931","doi":"10.3390/cells8020115","title":"Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideum","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"Natural Sciences and Engineering Research Council of Canada; Banting Research Foundation","keywords":"Dictyostelium; Dictyostelium discoideum; Biology; Model organism; Multicellular organism; Batten disease; Organism; Neurodegeneration; Amoeba (genus); Gene; Genome; Computational biology; Neuronal ceroid lipofuscinosis; Function (biology); Genetics; Neuroscience; Disease; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370166,0.0005944516,0.0007125822,0.001857124,0.0001920342,0.0005964917,0.0004121686,0.0005729072,0.0018642],"category_scores_gemma":[0.0004710161,0.0001925843,0.0003016395,0.001447594,0.0002970449,0.0007497258,0.0004337776,0.0009665212,0.001248486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005179528,"about_ca_system_score_gemma":0.0007631523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101498,"about_ca_topic_score_gemma":0.001789106,"domain_scores_codex":[0.9999036,0.00001111848,0.00001736432,0.00002059548,0.00003820972,0.000009036204],"domain_scores_gemma":[0.9998247,0.00007322695,0.00002458442,0.000005065277,0.00005394832,0.00001844708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001245093,0.00005141251,0.0002733657,0.02715792,0.00009217926,0.0002804289,0.00008571281,0.0005388357,0.01232172,0.004791789,0.02392615,0.930356],"study_design_scores_gemma":[0.00001062998,0.00009737293,0.000775253,0.001780867,0.0001213071,0.0009357336,0.00004797768,0.0000949488,0.001837352,0.001352544,0.9929299,0.00001618937],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002129137,0.9984443,0.0001149193,0.0001678246,0.0000903679,0.000002125183,0.00002158609,0.000007355604,0.0009385728],"genre_scores_gemma":[0.0008569003,0.9983512,0.0001611908,0.0001102522,0.00004644313,0.000003394964,0.00003625929,0.000001029584,0.0004332454],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0018642,"threshold_uncertainty_score":0.006236374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029107138291583,"score_gpt":0.3573335974785831,"score_spread":0.2544228836494248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}