{"id":"W2912282097","doi":"10.1093/jncics/pky078","title":"The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations","year":2018,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; Medical Research Council; Institut Gustave-Roussy; Great Ormond Street Hospital for Children; Newcastle upon Tyne Hospitals NHS Foundation Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Trinity College Dublin; University of Aberdeen; University of Southampton; National Institute for Health and Care Research; Nottingham University Hospitals NHS Trust; University Hospitals of Leicester NHS Trust; Royal Marsden NHS Foundation Trust; Cancer Australia; National Health and Medical Research Council; Cancer Research UK; University of Nottingham; University of Glasgow; Central Manchester University Hospitals NHS Foundation Trust","keywords":"Medicine; Prospective cohort study; Hazard ratio; Breast cancer; Proportional hazards model; Obstetrics; Cohort; Retrospective cohort study; Cohort study; Confidence interval; Pregnancy; Internal medicine; Gynecology; Relative risk; Cancer; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002151,0.0001315644,0.0002682506,0.00003884845,0.0001695896,0.00001337131,0.00007801604,0.00004104374,0.0002586734],"category_scores_gemma":[0.0000330746,0.00007305839,0.00003349594,0.0002105419,0.0004245944,0.0000703519,0.00002055827,0.0001006953,0.000001306627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107327,"about_ca_system_score_gemma":0.0004240745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0061632,"about_ca_topic_score_gemma":0.009350556,"domain_scores_codex":[0.9990821,0.00001148368,0.0002204624,0.000205242,0.0002075782,0.0002730873],"domain_scores_gemma":[0.9991278,0.0001257802,0.0002455624,0.0002407624,0.0001778323,0.00008225969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0131017,0.0001779407,0.9094133,0.0006549855,0.0007819454,0.000004790324,0.01318833,0.0005247022,0.002498715,0.0007143175,0.00242995,0.0565093],"study_design_scores_gemma":[0.001794585,0.001025616,0.982584,0.0006679001,0.0001403414,0.00002172436,0.0007250254,0.0001399662,0.007780455,0.0002854721,0.004700964,0.0001339733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969884,0.000275444,0.00003737093,0.00125884,0.0001141582,0.0004734306,0.0004073631,0.00001591364,0.0004291433],"genre_scores_gemma":[0.9969648,0.001098005,0.00008555846,0.000123621,0.0002406038,0.0002554937,0.000001186847,0.00002315773,0.001207634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07317065,"threshold_uncertainty_score":0.9316956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401281090265373,"score_gpt":0.3080386135155628,"score_spread":0.2940258026129091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}