{"id":"W2912295484","doi":"10.1007/s10822-019-00189-w","title":"AZT acts as an anti-influenza nucleotide triphosphate targeting the catalytic site of A/PR/8/34/H1N1 RNA dependent RNA polymerase","year":2019,"lang":"en","type":"article","venue":"Journal of Computer-Aided Molecular Design","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Favipiravir; RNA polymerase; Polymerase; RNA-dependent RNA polymerase; Nucleotide; RNA; Influenza A virus; Virology; Biology; Chemistry; Transcription (linguistics); Viral replication; Molecular biology; Enzyme; Biochemistry; Virus; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214227,0.0003746886,0.000424121,0.0002174764,0.000277455,0.0003289886,0.0005451186,0.000557866,0.0019918],"category_scores_gemma":[0.0002217449,0.0001895202,0.0003102731,0.0001352012,0.0002922481,0.0002201506,0.0002030717,0.0005934346,0.0006573315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459166,"about_ca_system_score_gemma":0.0002548929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006562956,"about_ca_topic_score_gemma":0.0009570249,"domain_scores_codex":[0.9997867,0.00004186597,0.00001474229,0.00006108158,0.00006155583,0.0000341291],"domain_scores_gemma":[0.9999437,0.00001582201,0.00001482987,0.000006528047,0.000009084835,0.00001009013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000648907,0.00005157512,0.000305192,0.0001360282,0.00002669959,0.0001750262,0.00002010945,0.001032669,0.9866025,0.0005602023,0.0002967295,0.01014437],"study_design_scores_gemma":[0.00008932318,0.0006962221,0.0003491933,0.000005552158,0.00002998484,0.0002650916,0.00000563842,0.003104577,0.9907773,0.00008225408,0.004586404,0.000008463052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485076,0.007016901,0.0257771,0.0006216989,0.0004136936,0.0004038319,0.0009415296,0.0007566932,0.01556086],"genre_scores_gemma":[0.9847332,0.001620828,0.009953212,0.000159509,0.00002607382,0.0000791714,0.0003964067,0.00002629805,0.003005319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019918,"threshold_uncertainty_score":0.006663263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514156722393864,"score_gpt":0.3229457125966375,"score_spread":0.2878041453726989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}