{"id":"W2912295484","doi":"10.1007/s10822-019-00189-w","title":"AZT acts as an anti-influenza nucleotide triphosphate targeting the catalytic site of A/PR/8/34/H1N1 RNA dependent RNA polymerase","year":2019,"lang":"en","type":"article","venue":"Journal of Computer-Aided Molecular Design","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Favipiravir; RNA polymerase; Polymerase; RNA-dependent RNA polymerase; Nucleotide; RNA; Influenza A virus; Virology; Biology; Chemistry; Transcription (linguistics); Viral replication; Molecular biology; Enzyme; Biochemistry; Virus; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002731523,0.0004752843,0.00121297,0.0005018672,0.0001924863,0.0001375796,0.0007107013,0.0001517463,0.00007992253],"category_scores_gemma":[0.0006037835,0.0003340821,0.0005287242,0.0005087004,0.0001904967,0.0004871158,0.0002879622,0.0009614117,0.0001203362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351308,"about_ca_system_score_gemma":0.0007220778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001185526,"about_ca_topic_score_gemma":0.000001309316,"domain_scores_codex":[0.9947286,0.0006830896,0.001493509,0.0004289203,0.001864234,0.0008016527],"domain_scores_gemma":[0.9957877,0.0005132646,0.001249108,0.0008493823,0.001083898,0.0005166755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002294392,0.0005844159,0.001532457,0.0002737834,0.00151902,0.003090828,0.00130214,0.01631393,0.9628261,0.0002894168,0.001161666,0.008811818],"study_design_scores_gemma":[0.007822135,0.004010569,0.004088848,0.0008225415,0.0005581146,0.0006801863,0.0002623875,0.009633552,0.969906,0.0003147972,0.001420245,0.0004806286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514877,0.005524584,0.0404602,0.0005491992,0.0004564137,0.001056946,0.000007272608,0.00003684504,0.0004208104],"genre_scores_gemma":[0.9847347,0.0002798595,0.01167017,0.002808012,0.0003228844,0.000005311696,0.000004127241,0.00009083615,0.00008414656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03324692,"threshold_uncertainty_score":0.9999111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514156722393864,"score_gpt":0.3229457125966375,"score_spread":0.2878041453726989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}