{"id":"W2912342925","doi":"10.1093/annonc/mdz036","title":"Genomic alterations in breast cancer: level of evidence for actionability according to ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Context (archaeology); PTEN; Breast cancer; Cancer; Germline; Oncology; Genetics; Bioinformatics; Internal medicine; Gene; Biology; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02882235,0.000898761,0.002326699,0.009319192,0.0007987927,0.002553994,0.001250654,0.001485843,0.007133573],"category_scores_gemma":[0.04061878,0.0002853065,0.006040017,0.005110845,0.001164969,0.001558146,0.002459469,0.001157328,0.001043385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001490589,"about_ca_system_score_gemma":0.001430331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002050098,"about_ca_topic_score_gemma":0.005538383,"domain_scores_codex":[0.9813426,0.005100152,0.005578788,0.0009221932,0.006350615,0.0007055609],"domain_scores_gemma":[0.9408036,0.03427204,0.01076145,0.001975265,0.01030184,0.001885689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007603985,0.0002422042,0.5511002,0.02855721,0.02442358,0.0006217871,0.0002995901,0.003023753,0.006589882,0.003860626,0.01706289,0.3566144],"study_design_scores_gemma":[0.001171445,0.005785284,0.8369432,0.01362509,0.02629121,0.002962387,0.001130375,0.005943866,0.004707464,0.01462847,0.08660259,0.0002086419],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2856866,0.515922,0.02461639,0.02668215,0.00172195,0.003333769,0.04084158,0.000648018,0.1005475],"genre_scores_gemma":[0.9408978,0.02580917,0.01872998,0.003238586,0.0006181975,0.0007422708,0.007810115,0.00007862079,0.002075238],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02882235,"threshold_uncertainty_score":0.152429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2850246893901123,"score_gpt":0.4942545931218036,"score_spread":0.2092299037316913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}