{"id":"W2912342925","doi":"10.1093/annonc/mdz036","title":"Genomic alterations in breast cancer: level of evidence for actionability according to ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Context (archaeology); PTEN; Breast cancer; Cancer; Germline; Oncology; Genetics; Bioinformatics; Internal medicine; Gene; Biology; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007937347,0.00009830056,0.0003909236,0.00005746611,0.00002140582,0.000002846032,0.0001806388,0.0001759783,0.00001358538],"category_scores_gemma":[0.000687541,0.00009933046,0.000220392,0.00007654475,0.00009971961,0.000008069415,0.00009568499,0.00005634463,5.753946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005725043,"about_ca_system_score_gemma":0.00071591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004436267,"about_ca_topic_score_gemma":0.0006311332,"domain_scores_codex":[0.9987106,0.0000666924,0.0006252541,0.0003496905,0.00006528429,0.0001824442],"domain_scores_gemma":[0.9982056,0.0004863243,0.000285727,0.0003234971,0.0006360762,0.00006278673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002341674,0.000500935,0.272754,0.0001984947,0.00007415087,9.984256e-8,0.00005395075,0.003564209,0.6976361,0.0001400249,0.001340937,0.0213954],"study_design_scores_gemma":[0.001392272,0.002511761,0.4839769,0.00005890267,0.00004003843,0.000002734326,0.0001320999,0.0002607659,0.499828,0.0009572805,0.01065727,0.0001819498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901713,0.0003286196,0.00436218,0.002889717,0.000330624,0.0009050194,0.0009764352,0.000001487442,0.0000346182],"genre_scores_gemma":[0.9949378,0.0007175952,0.003535935,0.000436218,0.0001114506,0.0001796835,0.00004491479,0.00001152038,0.0000248258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2112229,"threshold_uncertainty_score":0.4050578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2850246893901123,"score_gpt":0.4942545931218036,"score_spread":0.2092299037316913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}