{"id":"W2912344179","doi":"10.1126/science.aat7186","title":"Epithelial endoplasmic reticulum stress orchestrates a protective IgA response","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Pediatric Scientist Development Program; National Cancer Institute; European Research Council; Harvard Digestive Diseases Center, Harvard University; Japan Foundation for Applied Enzymology; National Institutes of Health; NIH Office of the Director; Japan Society for the Promotion of Science; Evelyn Trust; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Crohn's and Colitis Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Wellcome; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Unfolded protein response; Immunoglobulin A; Lamina propria; Inflammation; Immunology; Autophagy; Cell biology; Antibody; Biology; Tight junction; Secretory IgA; Immunoglobulin G; Epithelium; Chemistry; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676946,0.0002842422,0.0003031774,0.0002297217,0.0002210489,0.0005039308,0.0001119105,0.0004540432,0.0007735596],"category_scores_gemma":[0.0001086232,0.0001207467,0.000310575,0.0001057601,0.0002873813,0.0003159211,0.0005270977,0.0005909067,0.0005272434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072845,"about_ca_system_score_gemma":0.0001616737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981171,"about_ca_topic_score_gemma":0.0002180819,"domain_scores_codex":[0.9998016,0.00003346463,0.00001444688,0.00004850934,0.00002747103,0.00007462074],"domain_scores_gemma":[0.9998883,0.000005851598,0.00002847209,0.00001379965,0.00002423043,0.00003932837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005264044,0.00002849409,0.001497807,0.000104904,0.00001360041,0.0002655069,0.00006429666,0.0000528005,0.9931586,0.0003002914,0.0002828632,0.003704513],"study_design_scores_gemma":[0.000100094,0.001107912,0.1534886,0.0001028668,0.0001172554,0.002032474,0.0009650507,0.002079398,0.8132539,0.001799125,0.02491148,0.00004188161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851331,0.008297375,0.002195608,0.0006121477,0.0001756822,0.00002764923,0.0003052898,0.0001762568,0.00307686],"genre_scores_gemma":[0.9958271,0.001456357,0.0007398548,0.0001432531,0.00004211504,0.00001256854,0.0001671872,0.00001380386,0.001597639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007735596,"threshold_uncertainty_score":0.002587795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00737563554297441,"score_gpt":0.2312256051645409,"score_spread":0.2238499696215665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}