{"id":"W2912344179","doi":"10.1126/science.aat7186","title":"Epithelial endoplasmic reticulum stress orchestrates a protective IgA response","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Pediatric Scientist Development Program; National Cancer Institute; European Research Council; Harvard Digestive Diseases Center, Harvard University; Japan Foundation for Applied Enzymology; National Institutes of Health; NIH Office of the Director; Japan Society for the Promotion of Science; Evelyn Trust; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Crohn's and Colitis Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Wellcome; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Unfolded protein response; Immunoglobulin A; Lamina propria; Inflammation; Immunology; Autophagy; Cell biology; Antibody; Biology; Tight junction; Secretory IgA; Immunoglobulin G; Epithelium; Chemistry; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006323699,0.00009546221,0.000102535,0.0001397691,0.0002192859,0.00003807246,0.0002454807,0.00007866539,0.001410497],"category_scores_gemma":[0.0003214689,0.00007796121,0.00003930041,0.0003032578,0.0004758027,0.0002987545,0.00006368801,0.0002594419,0.005636776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006085926,"about_ca_system_score_gemma":0.0002102369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004330682,"about_ca_topic_score_gemma":0.000003785161,"domain_scores_codex":[0.9990342,0.000165609,0.0001352465,0.0003187181,0.00005508356,0.0002911935],"domain_scores_gemma":[0.9994247,0.0001133778,0.00007307917,0.000248485,0.0001234355,0.00001693346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007486378,0.00003671383,0.0005560227,0.000003556142,0.000007062495,9.245675e-7,0.000407824,0.000009495863,0.9973834,0.0002203363,0.000112955,0.000513068],"study_design_scores_gemma":[0.0004487339,0.0003302475,0.0169875,0.00002717894,0.000003690029,0.00005290623,0.0008474527,0.00004374619,0.9645519,0.00006102964,0.01654147,0.0001041752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926654,0.00009137073,0.00006605197,0.0002243758,0.003602924,0.0003012675,0.000004431715,0.0000601459,0.00298409],"genre_scores_gemma":[0.9801828,0.000004284194,0.00002357676,0.00008632493,0.000009907162,0.00001947064,0.000004392076,0.000005273157,0.01966397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03283153,"threshold_uncertainty_score":0.9995024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00737563554297441,"score_gpt":0.2312256051645409,"score_spread":0.2238499696215665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}