{"id":"W2912419839","doi":"10.1016/j.bpj.2018.11.2582","title":"The Weak Enzymatic Activity of Truncated Lecithin Retinol Acyltransferase (LRAT) Mutants cannot be Explained by their Affinity for All-Trans Retinol","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Acyltransferase; Dissociation constant; Mutant; Biochemistry; Enzyme; Chemistry; Stereochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587445,0.0006513641,0.0005093426,0.0003111763,0.0001962603,0.0006578618,0.0004926121,0.0004789716,0.00266015],"category_scores_gemma":[0.0005979879,0.0002349122,0.0005264076,0.0002817014,0.0005351984,0.0004213397,0.0003562297,0.001434481,0.001515446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005638946,"about_ca_system_score_gemma":0.0003934878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002570487,"about_ca_topic_score_gemma":0.00191127,"domain_scores_codex":[0.9996165,0.0000538567,0.00008382677,0.00007191423,0.0001034988,0.00007035916],"domain_scores_gemma":[0.9994084,0.0001734563,0.00009187718,0.0001086664,0.00008931015,0.0001283399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009628099,0.00001213177,0.0001993026,0.00001851439,0.000009142092,0.0000457512,0.00001441031,0.00003807411,0.9989991,0.00008290874,0.00002459983,0.0004599284],"study_design_scores_gemma":[0.000006113072,0.00003690116,0.001407882,0.000001963134,0.00001173771,0.0002950309,0.00002376137,0.0004513061,0.9966583,0.00005621219,0.001046172,0.000004584565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880362,0.0006253142,0.008308819,0.0003706121,0.0000970855,0.00002111479,0.001095016,0.0002611836,0.001184823],"genre_scores_gemma":[0.9889108,0.0002591152,0.004268847,0.00009549813,0.0000103979,0.00003380881,0.002237051,0.0001462654,0.004038233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266015,"threshold_uncertainty_score":0.008899093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202615371590735,"score_gpt":0.2477335625328023,"score_spread":0.235707408816895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}