{"id":"W2912422712","doi":"10.1074/jbc.ra118.005135","title":"The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Diabetes Canada; Centre hospitalier universitaire de Québec; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Wallonie-Bruxelles International; Alberta Diabetes Foundation; Alberta Innovates; Government of Canada","keywords":"Nerve growth factor IB; Nuclear receptor; Biology; Gene knockdown; Glucose homeostasis; Neuron-derived orphan receptor 1; Knockout mouse; Apoptosis; Orphan receptor; Endocrinology; Islet; Cell; Cell biology; Internal medicine; Receptor; Cancer research; Transcription factor; Genetics; Gene; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197927,0.0002866638,0.0003940402,0.0002618351,0.000173984,0.0003882324,0.0001653261,0.0001605105,0.002282289],"category_scores_gemma":[0.0001743971,0.00011467,0.0003359769,0.000174905,0.0002395863,0.0001551449,0.0002077799,0.0004313939,0.0003352638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002545471,"about_ca_system_score_gemma":0.0001492663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138955,"about_ca_topic_score_gemma":0.001699641,"domain_scores_codex":[0.9998797,0.00001283784,0.000007661733,0.00004745296,0.00002869438,0.00002368169],"domain_scores_gemma":[0.9998372,0.00001981854,0.00006275967,0.00001681824,0.00002811418,0.00003519357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000691179,0.00001266317,0.01216071,0.0001015895,0.00005350292,0.0002061635,0.0000377627,0.00003587556,0.9825439,0.00007404099,0.0001568834,0.003925711],"study_design_scores_gemma":[0.00005929919,0.0004880576,0.5626535,0.0000760371,0.0003318103,0.003285696,0.000489773,0.0008776592,0.4217538,0.0005104997,0.00943142,0.00004246932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856815,0.006914965,0.002439514,0.0002407312,0.0001197292,0.000009558959,0.00246043,0.0001164624,0.002017068],"genre_scores_gemma":[0.9919714,0.002039801,0.00138913,0.0001315965,0.00002833661,0.00001852217,0.001631143,0.00003911716,0.002750851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002282289,"threshold_uncertainty_score":0.007634997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958379987716567,"score_gpt":0.2299296337449554,"score_spread":0.2103458338677898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}