{"id":"W2912422712","doi":"10.1074/jbc.ra118.005135","title":"The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Diabetes Canada; Centre hospitalier universitaire de Québec; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Wallonie-Bruxelles International; Alberta Diabetes Foundation; Alberta Innovates; Government of Canada","keywords":"Nerve growth factor IB; Nuclear receptor; Biology; Gene knockdown; Glucose homeostasis; Neuron-derived orphan receptor 1; Knockout mouse; Apoptosis; Orphan receptor; Endocrinology; Islet; Cell; Cell biology; Internal medicine; Receptor; Cancer research; Transcription factor; Genetics; Gene; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003276688,0.0001302981,0.0002818276,0.00001395985,0.0001026905,0.00004154549,0.0005225433,0.0001528204,0.002640245],"category_scores_gemma":[0.0004448486,0.00006987383,0.0002316732,0.0001392936,0.0002190242,0.00006644908,0.000079591,0.0003909171,0.00009089964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003927083,"about_ca_system_score_gemma":0.0000354391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.754855e-7,"about_ca_topic_score_gemma":1.374163e-8,"domain_scores_codex":[0.9987704,0.00008224107,0.0004532204,0.0001917396,0.0002853463,0.0002170369],"domain_scores_gemma":[0.9985844,0.0004008589,0.0006095536,0.0001863394,0.0001031236,0.0001157448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002027009,0.00005421785,0.0002922526,0.00001676558,0.000007412826,0.000004018265,0.00008669699,0.000002501097,0.9975675,0.00004033385,0.001273458,0.0004521648],"study_design_scores_gemma":[0.000382765,0.0002362833,0.0000904869,0.0000377029,0.000005505269,0.00002307187,0.0002882556,0.00004501604,0.9759724,0.0003596728,0.02246319,0.00009566203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950128,0.00007396672,0.00000495734,0.0003810951,0.0001954788,0.00006409873,0.000010077,0.000009638798,0.004247902],"genre_scores_gemma":[0.9977517,0.0001894455,0.0003810031,0.0002566131,0.0001746584,3.744628e-7,2.201198e-7,0.00001285475,0.001233193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02159509,"threshold_uncertainty_score":0.9982715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958379987716567,"score_gpt":0.2299296337449554,"score_spread":0.2103458338677898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}