{"id":"W2912459593","doi":"10.1007/s10539-018-9659-6","title":"Mutationism, not Lamarckism, captures the novelty of CRISPR–Cas","year":2019,"lang":"en","type":"article","venue":"Biology & Philosophy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Novelty; Philosophy of biology; Inheritance (genetic algorithm); Mechanism (biology); Computer science; Cognitive science; Computational biology; Biology; Epistemology; Philosophy; Genetics; Psychology; Philosophy of science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229045,0.0001388798,0.0001544964,0.00003360071,0.00004344723,0.000006013261,0.0002414707,0.0001691908,0.0000382078],"category_scores_gemma":[0.00003868467,0.0001008964,0.0001117011,0.00005445489,0.0001259582,0.000001692455,0.00009677487,0.00009579682,0.00003201175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005073567,"about_ca_system_score_gemma":0.00003024368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002329623,"about_ca_topic_score_gemma":0.00000672747,"domain_scores_codex":[0.9992556,0.00004039336,0.0001945103,0.0002622839,0.00006556085,0.0001816479],"domain_scores_gemma":[0.9993966,0.00003177362,0.00007105267,0.0004061845,0.00006481878,0.00002956869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000519846,0.00003183186,0.00649767,0.00002592465,0.0000839288,7.708383e-7,0.00008735222,0.0003738319,0.9844233,0.00721946,0.0006494169,0.0005545326],"study_design_scores_gemma":[0.0006791052,0.0004275515,0.02699496,0.0000121885,0.00003234411,0.00002344287,0.00004552908,0.0001058587,0.929496,0.003695374,0.0382266,0.0002610125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879308,0.001385162,0.004056545,0.001672306,0.0005273167,0.0002715003,0.0000543735,0.00001679902,0.0040852],"genre_scores_gemma":[0.9980657,0.00007154971,0.0002994541,0.0008722051,0.0003985249,0.00001405379,0.00009162461,0.00001728908,0.0001696281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05492726,"threshold_uncertainty_score":0.4114434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040039887359077,"score_gpt":0.3025565396182401,"score_spread":0.2921561407446493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}