{"id":"W2912467491","doi":"10.1111/imcb.12238","title":"Modulating antibody‐dependent cellular cytotoxicity of epidermal growth factor receptor‐specific heavy‐chain antibodies through hinge engineering","year":2019,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; National Research Council Canada; University of Ottawa","funders":"Centers for Disease Control and Prevention","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Immunoglobulin Fc Fragments; Hinge; Antibody; Protein engineering; Molecular biology; Recombinant DNA; Epidermal growth factor receptor; Biology; Epidermal growth factor; Receptor; Chemistry; Immunology; Immunoglobulin G; Monoclonal antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001314976,0.0002440117,0.0001296601,0.0001093754,0.00008026347,0.0001873292,0.0001663051,0.0001693449,0.0005749823],"category_scores_gemma":[0.0000921109,0.00006972215,0.000171253,0.00009328211,0.0001155322,0.0001413627,0.0001436342,0.0002547719,0.0001211054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593585,"about_ca_system_score_gemma":0.00008589066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003898909,"about_ca_topic_score_gemma":0.000485653,"domain_scores_codex":[0.9999241,0.00001133753,0.000007653208,0.000009775438,0.00002126804,0.00002598583],"domain_scores_gemma":[0.9999444,0.00001364125,0.0000151381,0.000008260664,0.000007529609,0.00001094111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003230496,0.00001817135,0.0001152082,0.0000137555,0.000003239923,0.00002169531,0.000005152871,0.0002493623,0.9989042,0.00003252531,0.000009951174,0.0005944486],"study_design_scores_gemma":[0.000007366772,0.0001585292,0.001042904,0.000001565277,0.000006017328,0.00008230091,0.000004948667,0.0007334809,0.9974419,0.000009805081,0.0005092547,0.000001931809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99774,0.000304992,0.001427646,0.00001264162,0.000004526577,0.00001370669,0.00006899828,0.00001936811,0.0004080999],"genre_scores_gemma":[0.9981139,0.0001814094,0.001292148,0.00002317918,0.000002270744,0.000008169406,0.0001005794,0.000004618475,0.0002738043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005749823,"threshold_uncertainty_score":0.001923501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843781668525873,"score_gpt":0.2705789353785609,"score_spread":0.2521411186933021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}