{"id":"W2912467491","doi":"10.1111/imcb.12238","title":"Modulating antibody‐dependent cellular cytotoxicity of epidermal growth factor receptor‐specific heavy‐chain antibodies through hinge engineering","year":2019,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; National Research Council Canada; University of Ottawa","funders":"Centers for Disease Control and Prevention","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Immunoglobulin Fc Fragments; Hinge; Antibody; Protein engineering; Molecular biology; Recombinant DNA; Epidermal growth factor receptor; Biology; Epidermal growth factor; Receptor; Chemistry; Immunology; Immunoglobulin G; Monoclonal antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387755,0.0002834278,0.0007386609,0.0001498423,0.0001087566,0.000008216763,0.0001716564,0.0003806469,0.0004704944],"category_scores_gemma":[0.00005461628,0.0002306667,0.0001398027,0.0001265282,0.0003466008,0.00008625222,0.0002398126,0.0005735311,0.00008781916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003337298,"about_ca_system_score_gemma":0.00004229384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267686,"about_ca_topic_score_gemma":0.000001715894,"domain_scores_codex":[0.998183,0.0001575416,0.0004739268,0.0004721639,0.0001298177,0.0005835751],"domain_scores_gemma":[0.9990678,0.0003119161,0.0001483881,0.0002844252,0.0001129701,0.00007450017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004604383,0.0001087144,0.1138854,0.0002612084,0.0001498612,0.00001932798,0.0003800086,0.000007601896,0.8811933,0.002991005,0.00001841939,0.0005247372],"study_design_scores_gemma":[0.001341346,0.001001735,0.0520068,0.00009643664,0.00001984168,0.00006598649,0.0002170158,0.0003875472,0.9411775,0.0002867343,0.003109495,0.0002895387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865253,0.01024192,0.0004320803,0.0004313494,0.0004290276,0.0003597422,0.00005641137,0.00004793715,0.001476254],"genre_scores_gemma":[0.9936085,0.004193449,0.001135469,0.00009188746,0.0001203826,0.000006618775,0.0001256634,0.00002399764,0.0006940217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06187863,"threshold_uncertainty_score":0.9406317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843781668525873,"score_gpt":0.2705789353785609,"score_spread":0.2521411186933021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}