{"id":"W2912471182","doi":"10.1182/blood-2018-99-119128","title":"Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Stem cell; Haematopoiesis; Myeloid; Cell biology; Progenitor cell; Myelopoiesis; CD34; S1PR1; Lymphopoiesis; Myeloid leukemia; Hematopoietic stem cell; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006332804,0.000125198,0.00009548345,0.0001412576,0.00009970625,0.0001629028,0.00006379366,0.0001101813,0.001510643],"category_scores_gemma":[0.0000623237,0.00005751898,0.0001329481,0.0001008178,0.0000846484,0.00005865371,0.000182858,0.0002609703,0.0003739225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001428546,"about_ca_system_score_gemma":0.0001660025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006740591,"about_ca_topic_score_gemma":0.0009164661,"domain_scores_codex":[0.9999529,0.000007356216,0.000003197289,0.00000724903,0.00001611613,0.00001316962],"domain_scores_gemma":[0.9999781,0.000003943799,0.000004778796,0.000002213915,0.000003358682,0.000007662765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002258357,0.00002249379,0.0006687054,0.00002667531,0.000003833243,0.00007977519,0.00002022631,0.00008597921,0.9964078,0.0001150262,0.0001405802,0.002203049],"study_design_scores_gemma":[0.00004873601,0.0005293896,0.02846854,0.00001152956,0.00002252339,0.0005028404,0.0001130792,0.002545908,0.9594253,0.000170888,0.008155557,0.000005582601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968709,0.0007063959,0.0007650394,0.0001009696,0.00001144898,0.00002734976,0.0003853214,0.00005090109,0.001081813],"genre_scores_gemma":[0.9971565,0.0003938356,0.0004543924,0.00005491501,0.000003769503,0.00002020821,0.0005535876,0.000005726833,0.001357037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510643,"threshold_uncertainty_score":0.005053639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075948579470966,"score_gpt":0.2314374670394364,"score_spread":0.2206779812447268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}