{"id":"W2912477560","doi":"10.1016/j.jcf.2019.01.011","title":"Methylomic correlates of autophagy activity in cystic fibrosis","year":2019,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Center for Clinical and Translational Science, University of Utah; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Center for Clinical and Translational Science, University of Illinois at Chicago; National Institute of General Medical Sciences; Meso Scale Diagnostics; Ohio State University","keywords":"Burkholderia cenocepacia; Autophagy; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; ATG12; Biology; DNA methylation; Immune system; Cell biology; Cancer research; Gene; Immunology; Gene expression; Genetics; Virulence; Apoptosis; ATG5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320043,0.0001636812,0.0003603054,0.0006118649,0.0003155383,0.0004720544,0.0001546974,0.0003424405,0.002127168],"category_scores_gemma":[0.0007098537,0.0001527456,0.0001955175,0.0005116182,0.0001884897,0.0002344302,0.0003424803,0.0003389195,0.0002636535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611994,"about_ca_system_score_gemma":0.00011973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077524,"about_ca_topic_score_gemma":0.001821844,"domain_scores_codex":[0.999837,0.00002426765,0.00001640344,0.00004254639,0.00003894915,0.00004066287],"domain_scores_gemma":[0.9995781,0.00007008356,0.0001805257,0.00003058231,0.00006594732,0.00007488505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004282453,0.00006643937,0.3135859,0.00009946318,0.0003128929,0.0002989423,0.0001454607,0.0002640817,0.6693864,0.0002982788,0.0002972806,0.01096237],"study_design_scores_gemma":[0.00002350701,0.0003129176,0.9546252,0.00002156859,0.0001039052,0.0007566383,0.000189358,0.0006464977,0.04214474,0.0003675215,0.0007908563,0.00001721695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971977,0.001135298,0.0003458319,0.00006775929,0.00001310158,0.000003740613,0.0007175435,0.00001310033,0.000505887],"genre_scores_gemma":[0.9987446,0.000193085,0.0002077839,0.00003790253,0.000009176762,0.000006679796,0.0004026935,0.000006464113,0.00039166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002127168,"threshold_uncertainty_score":0.007116079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139528627886029,"score_gpt":0.2970699125353867,"score_spread":0.2856746262565265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}