{"id":"W2912487578","doi":"10.1126/sciimmunol.aau8125","title":"Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; University of Guelph; University of Toronto; Montreal Neurological Institute and Hospital; Sunnybrook Hospital","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Hospital for Sick Children; Juvenile Diabetes Research Foundation United Kingdom; National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation Canada","keywords":"Autoimmunity; Commensalism; Immunology; Biology; Antibody; Islet; Human leukocyte antigen; Immune system; Bacteria; Antigen; Diabetes mellitus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008532737,0.0001049054,0.0001873865,0.0001488206,0.00005735432,0.00002343329,0.0004149135,0.00009854326,0.00001854143],"category_scores_gemma":[0.0003137436,0.00009389943,0.00002594514,0.0003552377,0.0001595615,0.00001197746,0.0002034527,0.000119702,0.00002262448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008825169,"about_ca_system_score_gemma":0.0002261936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493445,"about_ca_topic_score_gemma":0.00002941863,"domain_scores_codex":[0.9988609,0.0001459224,0.0002067037,0.0002756703,0.0001627865,0.0003480413],"domain_scores_gemma":[0.9993137,0.00003099441,0.0001767131,0.0003027591,0.0001480196,0.00002783193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007886328,0.00003917842,0.4579226,0.000002127438,0.00002128569,1.70925e-7,0.00004299,0.00001631584,0.5416605,0.00001517933,0.0000135077,0.0001873131],"study_design_scores_gemma":[0.000846873,0.0009002318,0.896315,0.00005407952,0.000007853255,0.00001412049,0.0003325213,0.00001299569,0.1012396,0.00001152543,0.0001195278,0.0001456671],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989435,0.00009961884,0.00002191781,0.0002216417,0.0001355224,0.0002470759,0.00001640747,0.00000868606,0.0003055937],"genre_scores_gemma":[0.9992988,0.00002210605,0.0001320498,0.0001056184,0.00000837253,0.000007774775,0.00004033703,0.000007681374,0.0003772711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4404208,"threshold_uncertainty_score":0.3829108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003354666146113227,"score_gpt":0.2386041085614294,"score_spread":0.2352494424153162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}