{"id":"W2912487578","doi":"10.1126/sciimmunol.aau8125","title":"Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; University of Guelph; University of Toronto; Montreal Neurological Institute and Hospital; Sunnybrook Hospital","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Hospital for Sick Children; Juvenile Diabetes Research Foundation United Kingdom; National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation Canada","keywords":"Autoimmunity; Commensalism; Immunology; Biology; Antibody; Islet; Human leukocyte antigen; Immune system; Bacteria; Antigen; Diabetes mellitus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003767727,0.0005116301,0.0003481766,0.0009254087,0.0003856406,0.0004136271,0.0002712578,0.0005089879,0.002925031],"category_scores_gemma":[0.001342904,0.0003663885,0.0003069232,0.0009478958,0.0006189867,0.0003848523,0.0004362662,0.0008051363,0.0002783514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552059,"about_ca_system_score_gemma":0.0003296071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002197432,"about_ca_topic_score_gemma":0.001916568,"domain_scores_codex":[0.9995528,0.0001136425,0.00004598694,0.0001332205,0.00007744176,0.00007684884],"domain_scores_gemma":[0.9991271,0.0001977077,0.0004031177,0.00005282844,0.0000556327,0.0001636203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002183742,0.00003827602,0.9910433,0.00003197838,0.00003230467,0.002328656,0.0001400256,0.00005552842,0.003069964,0.0001032055,0.0002540707,0.00268433],"study_design_scores_gemma":[0.00001110933,0.0001554387,0.9790315,0.00002940628,0.00005757437,0.01846691,0.0003608261,0.0001231644,0.001028517,0.0001121139,0.0006162111,0.00000723948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983102,0.0004757654,0.0002070238,0.0001140067,0.00001223497,0.000003998159,0.0001951808,0.00001033632,0.0006712244],"genre_scores_gemma":[0.9989844,0.0004133222,0.0002205722,0.00003237491,0.00001828372,0.000005467296,0.0001017115,0.000006352525,0.0002174504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002925031,"threshold_uncertainty_score":0.009785235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003354666146113227,"score_gpt":0.2386041085614294,"score_spread":0.2352494424153162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}