{"id":"W2912551414","doi":"10.1172/jci.insight.124575","title":"Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Mycophenolate; Mycophenolic acid; Lupus nephritis; Medicine; Immunology; Immune system; Systemic lupus erythematosus; Lupus erythematosus; Nephritis; Disease; Internal medicine; Antibody; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004440274,0.0003081506,0.0007108788,0.0004877756,0.00005566829,0.00004891578,0.0002278739,0.000205205,0.0004975492],"category_scores_gemma":[0.000175139,0.0002519834,0.0001209935,0.0006809251,0.00005061489,0.0002561241,0.0001134611,0.0003951503,0.002093579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000646673,"about_ca_system_score_gemma":0.0002459949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009110106,"about_ca_topic_score_gemma":0.0000120944,"domain_scores_codex":[0.9968167,0.0001552339,0.0008229316,0.0006064142,0.0009911767,0.0006075591],"domain_scores_gemma":[0.9983176,0.0001751419,0.0002380564,0.0007450387,0.0003106351,0.0002135154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00064812,0.0003810434,0.9785514,0.001416589,0.00007236536,0.00009960927,0.005548251,0.00002871496,0.01004948,0.0002385942,0.002122869,0.0008429664],"study_design_scores_gemma":[0.2026979,0.009842668,0.3672151,0.06356459,0.0007271532,0.0713002,0.0380352,0.02091524,0.145459,0.002857928,0.06932474,0.008060237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732774,0.001676626,0.000009382531,0.0001015278,0.001408054,0.002123717,0.00001002568,0.000124195,0.02126903],"genre_scores_gemma":[0.9902467,0.0001763474,0.0001216773,0.00007373257,0.0001051285,0.0001043177,0.00006516247,0.0000822748,0.009024631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6113363,"threshold_uncertainty_score":0.9999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139600774806376,"score_gpt":0.2623282671648597,"score_spread":0.2483681896842221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}