{"id":"W2912552280","doi":"10.1158/2159-8290.cd-18-1090","title":"Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Spinal Cord Injury BC; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Deutsche Krebshilfe; Terry Fox Research Institute; Michael Smith Health Research BC; Uehara Memorial Foundation","keywords":"Immune system; Biology; Major histocompatibility complex; Computational biology; Immune recognition; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002924306,0.0002143747,0.0002551025,0.000291214,0.0001042279,0.0003356548,0.0001681473,0.0003935893,0.0008052299],"category_scores_gemma":[0.0003677671,0.00008897973,0.000156588,0.0001959153,0.0003138414,0.0001877664,0.0001737122,0.0005064713,0.0002427227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003147046,"about_ca_system_score_gemma":0.0001499139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003958762,"about_ca_topic_score_gemma":0.0006698833,"domain_scores_codex":[0.9998534,0.00004018584,0.000008774436,0.00003876587,0.00003367479,0.00002509706],"domain_scores_gemma":[0.9998569,0.00005433535,0.00001926694,0.00001230282,0.00003218588,0.00002492759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003500484,0.0001616634,0.1785552,0.0002654046,0.0002333294,0.005258458,0.0001661216,0.0005616901,0.7141914,0.0009988984,0.006681282,0.08942597],"study_design_scores_gemma":[0.0004457259,0.002127103,0.5717782,0.00006925302,0.0003971229,0.02143949,0.0003751547,0.003539902,0.3557789,0.001531993,0.04247541,0.00004178776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766975,0.01316146,0.002635852,0.003541309,0.000159257,0.00003049852,0.0004847426,0.00005472029,0.003234527],"genre_scores_gemma":[0.9950278,0.002068345,0.0007539666,0.0005714494,0.0002229029,0.00001288358,0.0002343308,0.00001310685,0.001095152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008052299,"threshold_uncertainty_score":0.002693772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030182547025933,"score_gpt":0.2529846919510217,"score_spread":0.2439545094039958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}