{"id":"W2912552280","doi":"10.1158/2159-8290.cd-18-1090","title":"Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Spinal Cord Injury BC; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Deutsche Krebshilfe; Terry Fox Research Institute; Michael Smith Health Research BC; Uehara Memorial Foundation","keywords":"Immune system; Biology; Major histocompatibility complex; Computational biology; Immune recognition; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008033758,0.00009694447,0.0001193349,0.0000352082,0.00003363973,0.0000331167,0.00005877608,0.00007638169,0.0000153408],"category_scores_gemma":[0.00001908145,0.00009742741,0.00005818033,0.00005189003,0.00003183671,0.00001442851,0.00003083679,0.00002585822,0.000002082905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011841,"about_ca_system_score_gemma":0.00006214715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000199973,"about_ca_topic_score_gemma":0.000008603506,"domain_scores_codex":[0.9993339,0.00002589671,0.0002005236,0.0002376507,0.00007819568,0.0001239043],"domain_scores_gemma":[0.9995903,0.000009549541,0.0001343847,0.0001588658,0.00008644004,0.00002050863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004876369,0.0000167567,0.0027937,0.0001024353,0.00002313887,1.410348e-7,0.00004455199,0.000124689,0.9909286,0.00002966339,6.389188e-7,0.005886888],"study_design_scores_gemma":[0.0002988363,0.0002255408,0.0188217,0.00003918079,0.00003046201,6.651646e-7,0.00003559205,0.00008687624,0.9790955,0.0009761174,0.0002623566,0.0001272393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611999,0.008233604,0.02980913,0.00002791312,0.0002461327,0.0003354965,0.00005962685,0.000003520094,0.00008463427],"genre_scores_gemma":[0.9972973,0.001824971,0.0001622772,0.00005308132,0.00006054502,0.00005762552,0.0002954188,0.00001929859,0.0002294832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03609736,"threshold_uncertainty_score":0.3972974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030182547025933,"score_gpt":0.2529846919510217,"score_spread":0.2439545094039958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}